We describe a new algorithm, meraculous, for whole genome assembly of deep paired-end
short reads, and apply it to the assembly of a dataset of paired 75-bp Illumina reads derived …

Asked how mature the field of genome assembly is, Ian Korf at the University of California,
Davis, compares it to a teenager with great capabilities.“It's got bold assertions about what it …

Although many de novo genome assembly projects have recently been conducted using
high-throughput sequencers, assembling highly heterozygous diploid genomes is a …

Long road to long-read assembly | Nature Methods Skip to main content Thank you for
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Genome assemblies that are accurate, complete and contiguous are essential for identifying
important structural and functional elements of genomes and for identifying genetic variation …

The highly anticipated transition from next generation sequencing (NGS) to third generation
sequencing (3GS) has been difficult primarily due to high error rates and excessive …

Second-generation sequencing technology can now be used to sequence an entire human
genome in a matter of days and at low cost. Sequence read lengths, initially very short, have …

As the advent of next-generation sequencing (NGS) technology, various de novo assembly
algorithms based on the de Bruijn graph have been developed to construct chromosome …

We present new methods for the improvement of long-read de novo genome assembly
incorporated into a straightforward tool called Raven (https://github. com/lbcb-sci/raven) …

Low-cost short read sequencing technology has revolutionized genomics, though it is only
just becoming practical for the high-quality de novo assembly of a novel large genome. We …