The role of B cells in the pathogenesis of Multiple Sclerosis (MS), an autoimmune
neurodegenerative disease, is becoming eminent in recent years, but the specific …

Important antibody-independent pathogenic roles of B cells are emerging in autoimmune
diseases, including multiple sclerosis (MS). The contrasting results of different treatments …

Objective B cell targeted therapies have been effective in slowing multiple sclerosis (MS)
disease progression suggesting a direct causal link for this lymphoid subset. A small subset …

Multiple sclerosis (MS) is considered to be a T cell-mediated autoimmune disease that
results in the presence of inflammatory lesions/plaques associated with mononuclear cell …

Increasing evidence indicates the involvement of B cells in the pathogenesis of multiple
sclerosis (MS), but their precise roles are unclear. In this Review, we provide an overview of …

Regulatory B cell or “Breg” is a broad term that represents the anti-inflammatory activity of B
cells, but does not describe their individual phenotypes, specific mechanisms of regulation …

Background: Collectively, research on the role of B-cells in the pathogenesis of multiple
sclerosis (MS) illustrates how translational medicine has given rise to promising therapeutic …

Current clinical experience with immunomodulatory agents and monoclonal antibodies in
principle has established the benefit of depleting lymphocytic populations in relapsing …

Background B lymphocytes play a pivotal regulatory role in the development of the immune
response. It was previously shown that deficiency in B regulatory cells (Bregs) or a decrease …

There is ongoing debate on how B cells contribute to the pathogenesis of multiple sclerosis
(MS). The success of B‐cell targeting therapies in MS highlighted the role of B cells …