Nuclear receptors (NRs) are ligand-activated transcriptional regulators of several key
metabolic processes including hepatic lipid and glucose metabolism, bile acid homeostasis …

Nonalcoholic fatty liver disease (NAFLD) is a consequence of insulin resistance
encompassing a spectrum that extends from simple hepatic steatosis through to …

Non-alcoholic fatty liver disease (NAFLD) is a global health burden closely linked to insulin
resistance, obesity, and type 2 diabetes. The complex pathophysiology of NAFLD involves …

Non‐alcoholic fatty liver disease (NAFLD) is currently evolving as the most common liver
disease worldwide. It may progress to liver cirrhosis and liver cancer and is poised to …

Non-alcoholic fatty liver (NAFLD) over the past years has become a metabolic pandemic
linked to a collection of metabolic diseases. The nuclear receptors ERRs, REV-ERBs, RORs …

Cholestatic and non-alcoholic fatty liver disease (NAFLD) share several key
pathophysiological mechanisms which can be targeted by novel therapeutic concepts that …

Nuclear receptors are transcription factors which sense changing environmental or
hormonal signals and effect transcriptional changes to regulate core life functions including …

Nonalcoholic fatty liver disease (NAFLD) is primarily caused by abnormal lipid metabolism
and the accumulation of triglycerides in the liver. NAFLD is also associated with hepatic …

Members of the nuclear receptor (NR) superfamily of ligand‐activated transcription factors
are players of substantial relevance in the regulation of hepatic gene expression. NRs direct …

Ligand-activated nuclear receptors, including peroxisome proliferator-activated receptor
alpha (PPARα), pregnane X receptor, and constitutive androstane receptor, were first …