Abstract The Gram-negative pathogen Campylobacter jejuni is the most common cause of
bacterial foodborne disease worldwide. The mechanisms that lead to bacterial invasion of …

Citrobacter rodentium is an enteric bacterial pathogen of the mouse intestinal tract that
triggers inflammatory responses resembling those of humans infected with …

Background The inflammasome is an intracellular protein complex triggered by exposure to
intracellular pathogens, its components or other endogenous proteins. It leads to the …

Escherichia coli is a common cause of mastitis in dairy cows. The adaptor protein apoptosis-
associated speck-like protein containing a caspase recruitment domain (ASC) synergizes …

Background: Nod-like receptor family, pyrin domain containing 3 (NLRP3) is an important
cytosolic sensor of cellular stress and infection. Once activated, NLRP3 forms a multiprotein …

Salmonella enterica serovar Typhimurium is a Gram-negative pathogen that causes
diseases ranging from gastroenteritis to systemic infection and sepsis. Salmonella uses type …

Infection of human macrophages with Salmonella enterica serovar Typhimurium (S.
Typhimurium) leads to inflammasome activation. Inflammasomes are multiprotein …

Some strains of lactic acid bacteria (LAB) have anti-inflammatory effects, but the mechanism
underlying the alleviation of inflammation by LAB is not fully understood. In this study, we …

Large molecular complexes known as inflammasomes regulate the release of IL-1β from
immune cells in response to infection and injury. Salmonella typhimurium infection is …

Enteric pathogen–host interactions occur at multiple interfaces, including the intestinal
epithelium and deeper organs of the immune system. Microbial ligands and activities are …