Although nano-systems can promote the cellular internalization, polymeric nanoparticles
(NPs) are easily to be destroyed or eliminated in the gastrointestinal tract, which leads to …

Background The oral colon-targeting drug delivery vehicle is vital for the efficient application
of curcumin (Cur) in ulcerative colitis (UC) treatment because of its lipophilicity and instability …

The current study aimed to overcome the poor solubility and colon-specific delivery of
curcumin (CUR) by formulating a curcumin nanosuspension (CUR-NS) using the antisolvent …

(1) Background: In the treatment of ulcerative colitis (UC), accurate delivery and release of
anti-inflammatory drugs to the site of inflammation can reduce systemic side effects.(2) …

Although multitudinous nanoscale drug-delivery systems (DDSs) have been recommended
to improve anti-ulcerative colitis (UC) outcomes, to enhance the mucoadhesion of …

Curcumin (CUR) is a promising edible phytochemical compound with ideal ulcerative colitis
(UC) treatment activity; however, it is characteristically instable in the digestive tract and has …

Background Due to oral nano-delivery systems for the treatment of inflammatory bowel
disease (IBD) are often failed to accumulated to the colonic site and could not achieve …

In this study, we developed oral core–shell nanoparticles composed of curcumin
nanocrystals in the core and chitosan/alginate multilayers in the shell for inflammation …

Conventional oral therapy for ulcerative colitis (UC) is associated with premature release or
degradation of drugs in the harsh gastrointestinal environment, resulting in reduced …

The therapeutic efficacies of oral nanotherapeutics for ulcerative colitis (UC) are seriously
hindered by the lack of mucus-penetrating capacity and uncontrolled drug release. To …