High‐throughput sequencing of TCR repertoires in multiple sclerosis reveals intrathecal enrichment of EBV‐reactive CD8+ T cells

A Lossius, JN Johansen, F Vartdal… - European journal of …, 2014 - Wiley Online Library
Epstein‐Barr virus (EBV) has long been suggested as a pathogen in multiple sclerosis (MS).
Here, we used high‐throughput sequencing to determine the diversity …

Longitudinal analysis reveals high prevalence of Epstein-Barr virus associated with multiple sclerosis

K Bjornevik, M Cortese, BC Healy, J Kuhle, MJ Mina… - Science, 2022 - science.org
Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central
nervous system of unknown etiology. We tested the hypothesis that MS is caused by Epstein …

Epstein–Barr virus and multiple sclerosis

RM Lucas, AM Hughes, MLJ Lay… - Journal of Neurology …, 2011 - jnnp.bmj.com
This review of the considerable evidence linking Epstein–Barr virus (EBV) infection to risk
and disease progression in multiple sclerosis (MS) builds on the background to the virus …

Multiple sclerosis is linked to Epstein‐Barr virus infection

S Haahr, P Höllsberg - Reviews in medical virology, 2006 - Wiley Online Library
The aetiology and pathogenesis of MS are unknown, but environmental agents, genetic
susceptibility and stochastic events are likely to be involved. In order to evaluate the …

Association of innate immune activation with latent Epstein-Barr virus in active MS lesions

JS Tzartos, G Khan, A Vossenkamper, M Cruz-Sadaba… - Neurology, 2012 - AAN Enterprises
Objective: To determine whether the activation of innate immune responses, which can be
elicited by pathogenic and endogenous triggers, is associated with the presence of Epstein …

B-cell enrichment and Epstein-Barr virus infection in inflammatory cortical lesions in secondary progressive multiple sclerosis

R Magliozzi, B Serafini, B Rosicarelli… - … of Neuropathology & …, 2013 - academic.oup.com
Gray matter lesions are thought to play a key role in the progression of disability and
cognitive impairment in multiple sclerosis (MS) patients, but whether gray matter damage is …

[PDF][PDF] Ineffective control of Epstein-Barr-virus-induced autoimmunity increases the risk for multiple sclerosis

H Vietzen, SM Berger, LM Kühner, PL Furlano, G Bsteh… - Cell, 2023 - cell.com
Multiple sclerosis (MS) is a demyelinating disease of the CNS. Epstein-Barr virus (EBV)
contributes to the MS pathogenesis because high levels of EBV EBNA 386–405-specific …

Antibodies to Epstein-Barr virus and MRI disease activity in multiple sclerosis

S Kvistad, KM Myhr, T Holmøy, S Bakke… - Multiple Sclerosis …, 2014 - journals.sagepub.com
Background: Previous reports indicate an association between Epstein-Barr virus (EBV)
antibody levels and multiple sclerosis (MS) disease activity, but the results have been …

Clonally expanded B cells in multiple sclerosis bind EBV EBNA1 and GlialCAM

TV Lanz, RC Brewer, PP Ho, JS Moon, KM Jude… - Nature, 2022 - nature.com
Multiple sclerosis (MS) is a heterogenous autoimmune disease in which autoreactive
lymphocytes attack the myelin sheath of the central nervous system. B lymphocytes in the …

High levels of Epstein–Barr virus nuclear antigen-1-specific antibodies and infectious mononucleosis act both independently and synergistically to increase multiple …

AK Hedström, J Huang, A Michel, J Butt… - Frontiers in …, 2020 - frontiersin.org
Objective: Elevated levels of anti-EBNA-1 antibodies and infectious mononucleosis (IM)
history have consistently been associated with multiple sclerosis (MS) risk. We aimed to …