High‐throughput sequencing of TCR repertoires in multiple sclerosis reveals intrathecal enrichment of EBV‐reactive CD8+ T cells
A Lossius, JN Johansen, F Vartdal… - European journal of …, 2014 - Wiley Online Library
Epstein‐Barr virus (EBV) has long been suggested as a pathogen in multiple sclerosis (MS).
Here, we used high‐throughput sequencing to determine the diversity …
Here, we used high‐throughput sequencing to determine the diversity …
Longitudinal analysis reveals high prevalence of Epstein-Barr virus associated with multiple sclerosis
Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central
nervous system of unknown etiology. We tested the hypothesis that MS is caused by Epstein …
nervous system of unknown etiology. We tested the hypothesis that MS is caused by Epstein …
Epstein–Barr virus and multiple sclerosis
RM Lucas, AM Hughes, MLJ Lay… - Journal of Neurology …, 2011 - jnnp.bmj.com
This review of the considerable evidence linking Epstein–Barr virus (EBV) infection to risk
and disease progression in multiple sclerosis (MS) builds on the background to the virus …
and disease progression in multiple sclerosis (MS) builds on the background to the virus …
Multiple sclerosis is linked to Epstein‐Barr virus infection
S Haahr, P Höllsberg - Reviews in medical virology, 2006 - Wiley Online Library
The aetiology and pathogenesis of MS are unknown, but environmental agents, genetic
susceptibility and stochastic events are likely to be involved. In order to evaluate the …
susceptibility and stochastic events are likely to be involved. In order to evaluate the …
Association of innate immune activation with latent Epstein-Barr virus in active MS lesions
JS Tzartos, G Khan, A Vossenkamper, M Cruz-Sadaba… - Neurology, 2012 - AAN Enterprises
Objective: To determine whether the activation of innate immune responses, which can be
elicited by pathogenic and endogenous triggers, is associated with the presence of Epstein …
elicited by pathogenic and endogenous triggers, is associated with the presence of Epstein …
B-cell enrichment and Epstein-Barr virus infection in inflammatory cortical lesions in secondary progressive multiple sclerosis
R Magliozzi, B Serafini, B Rosicarelli… - … of Neuropathology & …, 2013 - academic.oup.com
Gray matter lesions are thought to play a key role in the progression of disability and
cognitive impairment in multiple sclerosis (MS) patients, but whether gray matter damage is …
cognitive impairment in multiple sclerosis (MS) patients, but whether gray matter damage is …
[PDF][PDF] Ineffective control of Epstein-Barr-virus-induced autoimmunity increases the risk for multiple sclerosis
Multiple sclerosis (MS) is a demyelinating disease of the CNS. Epstein-Barr virus (EBV)
contributes to the MS pathogenesis because high levels of EBV EBNA 386–405-specific …
contributes to the MS pathogenesis because high levels of EBV EBNA 386–405-specific …
Antibodies to Epstein-Barr virus and MRI disease activity in multiple sclerosis
S Kvistad, KM Myhr, T Holmøy, S Bakke… - Multiple Sclerosis …, 2014 - journals.sagepub.com
Background: Previous reports indicate an association between Epstein-Barr virus (EBV)
antibody levels and multiple sclerosis (MS) disease activity, but the results have been …
antibody levels and multiple sclerosis (MS) disease activity, but the results have been …
Clonally expanded B cells in multiple sclerosis bind EBV EBNA1 and GlialCAM
Multiple sclerosis (MS) is a heterogenous autoimmune disease in which autoreactive
lymphocytes attack the myelin sheath of the central nervous system. B lymphocytes in the …
lymphocytes attack the myelin sheath of the central nervous system. B lymphocytes in the …
High levels of Epstein–Barr virus nuclear antigen-1-specific antibodies and infectious mononucleosis act both independently and synergistically to increase multiple …
Objective: Elevated levels of anti-EBNA-1 antibodies and infectious mononucleosis (IM)
history have consistently been associated with multiple sclerosis (MS) risk. We aimed to …
history have consistently been associated with multiple sclerosis (MS) risk. We aimed to …