Adipose tissue macrophages: the inflammatory link between obesity and cancer?

M Wagner, ES Samdal Steinskog… - Expert opinion on …, 2015 - Taylor & Francis
Introduction: Obesity has increased dramatically over the last three decades. Thus,
epidemiological evidence linking obesity and cancer has ignited our interest in the …

[HTML][HTML] The adipocyte–macrophage relationship in cancer: A potential target for antioxidant therapy

S Sanhueza, L Simón, M Cifuentes, AFG Quest - Antioxidants, 2023 - mdpi.com
Obesity has emerged as a major public health concern with a staggering 39% worldwide
prevalence as of 2021. Given the magnitude of the problem and considering its association …

Obesity programs macrophages to support cancer progression

A Singh, SS Mayengbam, H Yaduvanshi, MR Wani… - Cancer research, 2022 - AACR
Obesity induces multifactorial effects such as dyslipidemia, insulin resistance, and arterial
hypertension that influence the progression of many diseases. Obesity is associated with an …

[HTML][HTML] The impact of obesity, adipose tissue, and tumor microenvironment on macrophage polarization and metastasis

O Habanjar, M Diab-Assaf, F Caldefie-Chezet, L Delort - Biology, 2022 - mdpi.com
Simple Summary The inflammatory adipose microenvironment in obesity plays a crucial role
in cancer development and metastases. By focusing on adipocytes and macrophages, as …

[HTML][HTML] Obesity and cancer: the role of adipose tissue and adipo-cytokines-induced chronic inflammation

R Divella, R De Luca, I Abbate, E Naglieri… - Journal of …, 2016 - ncbi.nlm.nih.gov
Adipose tissue in addition to its ability to keep lipids is now recognized as a real organ with
both metabolic and endocrine functions. Recent studies demonstrated that in obese animals …

Adipocytes: impact on tumor growth and potential sites for therapeutic intervention

S Hefetz-Sela, PE Scherer - Pharmacology & therapeutics, 2013 - Elsevier
The prevalence of obesity has increased dramatically in recent decades, reaching epidemic
proportions. It is becoming clear that obesity is associated not only with type 2 diabetes …

[HTML][HTML] Human adipose tissue macrophages display activation of cancer-related pathways

TH Mayi, M Daoudi, B Derudas, B Gross… - Journal of Biological …, 2012 - ASBMB
Obesity is associated with a significantly increased risk for cancer suggesting that adipose
tissue dysfunctions might play a crucial role therein. Macrophages play important roles in …

Cytokines, obesity, and cancer: new insights on mechanisms linking obesity to cancer risk and progression

CA Gilbert, JM Slingerland - Annual review of medicine, 2013 - annualreviews.org
Obesity is a problem of epidemic proportions in many developed nations. Increased body
mass index and obesity are associated with a significantly worse outcome for many cancers …

The role of immune dysfunction in obesity-associated cancer risk, progression, and metastasis

A Kulkarni, LW Bowers - Cellular and Molecular Life Sciences, 2021 - Springer
Obesity has been linked to an increased risk of and a worse prognosis for several types of
cancer. A number of interrelated mediators contribute to obesity's pro-tumor effects …

[HTML][HTML] Adipose tissue immunity and cancer

V Catalán, J Gómez-Ambrosi, A Rodríguez… - Frontiers in …, 2013 - frontiersin.org
Inflammation and altered immune response are important components of obesity and
contribute greatly to the promotion of obesity-related metabolic complications, especially …