Serum proteomics identifies biomarkers associated with the pathogenesis of idiopathic pulmonary fibrosis

L Wang, M Zhu, Y Li, P Yan, Z Li, X Chen… - Molecular & Cellular …, 2023 - ASBMB
The heterogeneity of idiopathic pulmonary fibrosis (IPF) limits its diagnosis and treatment.
The association between the pathophysiological features and the serum protein signatures …

Single cell RNA-seq and mass cytometry reveals a novel and a targetable population of macrophages in idiopathic pulmonary fibrosis

EA Ayaub, S Poli, J Ng, T Adams, J Schupp… - BioRxiv, 2021 - biorxiv.org
In this study, we leveraged a combination of single cell RNAseq, cytometry by time of flight
(CyTOF), and flow cytometry to study the biology of a unique macrophage population in …

CXC motif chemokine 13 (CXCL13) is a prognostic biomarker of idiopathic pulmonary fibrosis

LJ Vuga, JR Tedrow, KV Pandit, J Tan… - American journal of …, 2014 - atsjournals.org
Rationale: CXC motif chemokine 13 (CXCL13) mediates B-cell trafficking and is increased,
proportionately to disease activity, in many antibody-mediated syndromes. Dysregulated B …

A role for the terminal C5-C9 complement pathway in idiopathic pulmonary fibrosis

LIB Sikkeland, T Ueland, MB Lund, MT Durheim… - Frontiers in …, 2023 - frontiersin.org
Idiopathic pulmonary fibrosis (IPF) is a chronic progressive interstitial lung disease
characterized by damage to the alveolar epithelium, leading to fibrosis and excessive …

CAV1 is a prognostic predictor for patients with idiopathic pulmonary fibrosis and lung cancer

D Yin, J Qiu, S Hu, L Cheng, H Li, X Cheng… - Journal of …, 2022 - Springer
The extremely high mortality of both lung cancer and Idiopathic pulmonary fibrosis (IPF) is a
global threat. Early detection and diagnosis can reduce their mortality. Since fibrosis is a …

Effect of M6A regulators on diagnosis, subtype classification, prognosis and novel therapeutic target development of idiopathic pulmonary fibrosis

G Huang, S Huang, H Cui - Frontiers in Pharmacology, 2022 - frontiersin.org
Molecular biology studies show that RNA N6-methyladenosine (m6A) modifications may
take part in the incidence and development of idiopathic pulmonary fibrosis (IPF) …

Prominence of IL6, IGF, TLR, and bioenergetics pathway perturbation in lung tissues of scleroderma patients with pulmonary fibrosis

L Renaud, WA Da Silveira, N Takamura… - Frontiers in …, 2020 - frontiersin.org
Scleroderma-associated pulmonary fibrosis (SSc-PF) and idiopathic pulmonary fibrosis (IPF)
are two of many chronic fibroproliferative diseases that are responsible for nearly 45% of all …

[HTML][HTML] Identification of transcriptomic markers for developing idiopathic pulmonary fibrosis: an integrative analysis of gene expression profiles

D Li, Y Liu, B Wang - International Journal of Clinical and …, 2020 - ncbi.nlm.nih.gov
Idiopathic pulmonary fibrosis (IPF) remains a lethal disease with unknown etiology and
unmet medical need. The aim of this study was to perform an integrative analysis of multiple …

Integrative omics analysis identifies biomarkers of idiopathic pulmonary fibrosis

P Zheng, S Sun, J Wang, ZJ Cheng, KC Lei… - Cellular and Molecular …, 2022 - Springer
Idiopathic pulmonary fibrosis (IPF) is an interstitial lung disease characterized by chronic
progressive pulmonary fibrosis and a poor prognosis. Genetic studies, including …

[HTML][HTML] PD-L1 on invasive fibroblasts drives fibrosis in a humanized model of idiopathic pulmonary fibrosis

Y Geng, X Liu, J Liang, DM Habiel, V Kulur, AL Coelho… - Jci Insight, 2019 - ncbi.nlm.nih.gov
Idiopathic pulmonary fibrosis (IPF) is a progressive disease with unremitting extracellular
matrix deposition, leading to a distortion of pulmonary architecture and impaired gas …