Birch pollinosis is one of the prevailing allergic diseases. In all, 5–20% of birch pollinotics
mount IgE antibodies against the minor birch pollen allergen Bet v 4, a Ca2+-binding …

Polcalcins such as Bet v 4 and Phl p 7 are pollen allergens that are constructed from EF‐
hand motifs, which are very common and well characterized helix–loop–helix motifs with …

The ability of pathogenesis-related proteins of family 10 to bind a broad spectrum of ligands
is considered to play a key role for their physiological and pathological functions. In …

Pathogenesis-related plant proteins of class-10 (PR-10) are essential for storage and
transport of small molecules. A prominent member of the PR-10 family, the major birch …

The 159 residue Bet v 1 is the major allergen from birch tree pollen. Its natural function is
unknown although it is capable of binding several types of physiologically relevant ligands …

Many allergens share several biophysical characteristics, including the capability to undergo
oligomerization. The dimerization mechanism in Bet v 1 and its allergenic properties are so …

The term allergy was coined in 1906 by the Austrian scientist and pediatrician Clemens
Freiherr von Pirquet. In 1976, Dietrich Kraft became the head of the Allergy and Immunology …

The major birch pollen allergen Bet v 1 is the main elicitor of airborne type I allergies and
belongs to the PR-10 family (pathogenesis-related proteins 10). Bet v 1 is the most …

We have isolated a cDNA clone coding for a birch pollen allergen, Bet v 4. The deduced
amino acid sequence of Bet v 4 contained two typical EF-hand calcium-binding domains …

The protein Bet v 1 represents the main cause for allergic reactions to birch pollen in Europe
and North America. Structurally homologous isoforms of Bet v 1 can have different properties …