Targeted delivery systems for biological therapies of inflammatory diseases

TH Tran, MM Amiji - Expert opinion on drug delivery, 2015 - Taylor & Francis
Introduction: Inflammatory diseases, including autoimmune diseases and autoinflammatory
diseases, are characterized by the imbalance of pro-inflammatory cytokines and anti …

Bioresponsive drug delivery systems for the treatment of inflammatory diseases

Y Dou, C Li, L Li, J Guo, J Zhang - Journal of controlled release, 2020 - Elsevier
Inflammation is intimately related to the pathogenesis of numerous acute and chronic
diseases like cardiovascular disease, inflammatory bowel disease, rheumatoid arthritis, and …

Macrophage-targeted delivery systems for nucleic acid therapy of inflammatory diseases

A Singh, M Talekar, A Raikar, M Amiji - Journal of controlled release, 2014 - Elsevier
Inflammation is an immune response that marks several pathophysiological conditions in
our body. Though adaptive immune cells play a major role in the progression of the disease …

Drug delivery to macrophages: a review of targeting drugs and drug carriers to macrophages for inflammatory diseases

W He, N Kapate, CW Shields IV, S Mitragotri - Advanced drug delivery …, 2020 - Elsevier
Macrophages play a key role in defending against foreign pathogens, healing wounds, and
regulating tissue homeostasis. Driving this versatility is their phenotypic plasticity, which …

Emerging drug delivery systems with traditional routes–A roadmap to chronic inflammatory diseases

K Min, A Sahu, SH Jeon, G Tae - Advanced Drug Delivery Reviews, 2023 - Elsevier
Inflammation is prevalent and inevitable in daily life but can generally be accommodated by
the immune systems. However, incapable self-healing and persistent inflammation can …

[HTML][HTML] Macrophage based drug delivery: Key challenges and strategies

Q Guo, ZM Qian - Bioactive Materials, 2024 - Elsevier
As a natural immune cell and antigen presenting cell, macrophages have been studied and
engineered to treat human diseases. Macrophages are well-suited for use as drug carriers …

[HTML][HTML] Macrophage-related therapeutic strategies: regulation of phenotypic switching and construction of drug delivery systems

X Wang, Y Li, X Pu, G Liu, H Qin, W Wan… - Pharmacological …, 2023 - Elsevier
Macrophages, as highly phenotypic plastic immune cells, play diverse roles in different
pathological conditions. Changing and controlling the phenotypes of macrophages is …

Harnessing anti-inflammatory pathways and macrophage nano delivery to treat inflammatory and fibrotic disorders

A Zaid, A Ariel - Advanced Drug Delivery Reviews, 2024 - Elsevier
Targeting specific organs and cell types using nanotechnology and sophisticated delivery
methods has been at the forefront of applicative biomedical sciences lately. Macrophages …

Recent advances in liposomal-based anti-inflammatory therapy

CMA van Alem, JM Metselaar, C van Kooten… - Pharmaceutics, 2021 - mdpi.com
Liposomes can be seen as ideal carriers for anti-inflammatory drugs as their ability to
(passively) target sites of inflammation and release their content to inflammatory target cells …

Macrophage-targeted therapeutics for metabolic disease

KR Peterson, MA Cottam, AJ Kennedy… - Trends in pharmacological …, 2018 - cell.com
Macrophages are cells of the innate immune system that are resident in all tissues, including
metabolic organs such as the liver and adipose tissue (AT). Because of their phenotypic …