Macrophage-targeted therapeutics for metabolic disease

KR Peterson, MA Cottam, AJ Kennedy… - Trends in pharmacological …, 2018 - cell.com
Macrophages are cells of the innate immune system that are resident in all tissues, including
metabolic organs such as the liver and adipose tissue (AT). Because of their phenotypic …

Local delivery strategies to restore immune homeostasis in the context of inflammation

ER Bentley, SR Little - Advanced drug delivery reviews, 2021 - Elsevier
Immune homeostasis is maintained by a precise balance between effector immune cells and
regulatory immune cells. Chronic deviations from immune homeostasis, driven by a greater …

Delivery strategies to control inflammatory response: Modulating M1–M2 polarization in tissue engineering applications

MM Alvarez, JC Liu, G Trujillo-de Santiago… - Journal of Controlled …, 2016 - Elsevier
Macrophages are key players in many physiological scenarios including tissue
homeostasis. In response to injury, typically the balance between macrophage sub …

Drug delivery strategies to control macrophages for tissue repair and regeneration

R Garash, A Bajpai… - Experimental biology …, 2016 - journals.sagepub.com
Tissue repair and regeneration is a complex process. Our bodies have an excellent capacity
to regenerate damaged tissues in many situations. However, tissue healing is impaired in …

Local drug delivery systems for inflammatory diseases: Status quo, challenges, and opportunities

YC Chen, SF Gad, D Chobisa, Y Li, Y Yeo - Journal of controlled release, 2021 - Elsevier
Inflammation that is not resolved in due course becomes a chronic disease. The treatment of
chronic inflammatory diseases involves a long-term use of anti-inflammatory drugs such as …

An overview on macrophage targeting: a promising approach

VD Vemuri, R Kushwaha, G Gowri… - Critical Reviews™ in …, 2023 - dl.begellhouse.com
Macrophages are immuno cells with high flexibility among hematopoietic system.
Macrophages are tangled with many diseases like chronic inflammatory, atherosclerosis …

Macrophage-associated disorders: pathophysiology, treatment challenges, and possible solutions

K Yadav, M Pradhan, D Singh, MR Singh - Macrophage Targeted Delivery …, 2022 - Springer
Immune disorders are a self-attacking state of our defense mechanism influencing diverse
body tissues and organs. One of the most significant obstacles in treatment for immune …

Advancements in macrophage-targeted drug delivery for effective disease management

H Liu, H Lv, X Duan, Y Du, Y Tang… - International Journal of …, 2023 - Taylor & Francis
Macrophages play a crucial role in tissue homeostasis and the innate immune system. They
perform essential functions such as presenting antigens, regulating cytokines, and …

Multi-compartmental nanoparticles-in-emulsion formulation for macrophage-specific anti-inflammatory gene delivery

H Attarwala, M Amiji - Pharmaceutical research, 2012 - Springer
Purpose To develop a safe and effective non-viral vector for gene delivery and transfection
in macrophages for potential anti-inflammatory therapy. Methods Solid nanoparticles-in …

Targeting monocyte and macrophage subpopulations for immunotherapy: a patent review (2009–2013)

WD Jackson, KJ Woollard - Expert Opinion on Therapeutic Patents, 2014 - Taylor & Francis
Introduction: Monocytes and macrophages are heterogeneous populations of effector cells
in the innate immune system. Once thought to be obligatory precursors for macrophages …