Oncolytic viruses (OVs), above and beyond infecting and lysing malignant cells, interact with
the immune system in complex ways that have important therapeutic significance. While …

Oncolytic viruses (OVs), viruses engineered to lyse tumor cells, work hand in hand with the
immune response. While for decades the field isolated lytic capability and viral spread to …

Oncolytic viruses (OVs) constitute a new and promising immunotherapeutic approach
toward cancer treatment. This therapy takes advantage of the natural propensity of most …

The field of oncolytic virus (OV) therapy is an innovative and evolving science, taking
advantage of the ability of select viruses to preferentially infect and kill human tumor cells …

Oncolytic viruses (OVs) are an emerging class of targeted anticancer therapies designed to
selectively infect, replicate in, and lyse malignant cells without causing harm to normal …

Highlights•Oncolytic viruses (OVs) elicit innate and adaptive immune responses against
tumors.•Although the immune system can react against OVs, a functional immune system is …

Oncolytic viruses (OVs), viruses that specifically result in killing tumor cells, represent a
promising class of cancer therapy. Recently, the focus in the OV therapy field has shifted …

Highlights•Oncolytic viral therapy triggers a number of host responses including anti-viral
and anti-tumor responses.•Increasing evidence suggests that both facets of the immune …

Cancer Immunotherapy relies on harnessing a patient's immune system to fine-tune specific
anti-tumor responses and ultimately eradicate cancer. Among diverse therapeutic …

Oncolytic viruses consist of a diverse range of DNA and RNA viruses traditionally thought to
mediate their effects by exploiting aberrations in tumor pathways, allowing preferential viral …