Copy number abnormalities (CNAs) in tumor cells are presumed to affect expression levels
of genes located in region of abnormality. To investigate this relationship we have surveyed …

Background Genomic hybridization platforms, including BAC-CGH and genotyping arrays,
have been used to estimate chromosome copy number (CN) in tumor samples by detecting …

We have undertaken an extensive high‐resolution analysis of loss of heterozygosity (LOH)
in 30 high grade gliomas using the Affymetrix 100K SNP mapping array. Only 70% of LOH …

Primary brain tumors are a major cause of cancer mortality in the United States. Therapy for
gliomas, the most common type of primary brain tumors, remains suboptimal. The …

Glioblastoma multiforme shows multiple chromosomal aberrations, the impact of which on
gene expression remains unclear. To investigate this relationship and to identify putative …

Alterations in the genome that lead to changes in DNA sequence copy number are a
characteristic of Glioblastomas (GBs). Microarray-based comparative genomic hybridization …

Identification of genetic copy number changes in glial tumors is of importance in the context
of improved/refined diagnostic, prognostic procedures and therapeutic decision-making. In …

Gene copy-number abnormalities (CNAs) are characteristic of solid tumors and are found in
association with developmental abnormalities and/or mental retardation. The ultimate impact …

Background Glioblastoma multiforme (GBM) displays multiple amplicons and homozygous
deletions that involve relevant pathogenic genes and other genes whose role remains …

Background Conventional cytogenetic and comparative genomic hybridization (CGH)
studies in brain malignancies have shown that glioblastoma multiforme (GBM) is …