Suppression of proliferative defects associated with processing-defective lamin A mutants by hTERT or inactivation of p53
BA Kudlow, MN Stanfel, CR Burtner… - Molecular biology of …, 2008 - Am Soc Cell Biol
Hutchinson-Gilford progeria syndrome (HGPS) is a rare, debilitating disease with early
mortality and rapid onset of aging-associated pathologies. It is linked to mutations in LMNA …
mortality and rapid onset of aging-associated pathologies. It is linked to mutations in LMNA …
A lamin A protein isoform overexpressed in Hutchinson–Gilford progeria syndrome interferes with mitosis in progeria and normal cells
Hutchinson–Gilford progeria syndrome (HGPS) is a rare genetic disorder characterized by
dramatic premature aging. Classic HGPS is caused by a de novo point mutation in exon 11 …
dramatic premature aging. Classic HGPS is caused by a de novo point mutation in exon 11 …
Inhibiting farnesylation reverses the nuclear morphology defect in a HeLa cell model for Hutchinson-Gilford progeria syndrome
MP Mallampalli, G Huyer, P Bendale… - Proceedings of the …, 2005 - National Acad Sciences
Hutchinson-Gilford progeria syndrome (HGPS) is a devastating premature aging disease
resulting from a mutation in the LMNA gene, which encodes nuclear lamins A and C. Lamin …
resulting from a mutation in the LMNA gene, which encodes nuclear lamins A and C. Lamin …
Defective lamin A-Rb signaling in Hutchinson-Gilford Progeria Syndrome and reversal by farnesyltransferase inhibition
J Marji, SI O'Donoghue, D McClintock, VP Satagopam… - PloS one, 2010 - journals.plos.org
Hutchinson-Gilford Progeria Syndrome (HGPS) is a rare premature aging disorder caused
by a de novo heterozygous point mutation G608G (GGC> GGT) within exon 11 of LMNA …
by a de novo heterozygous point mutation G608G (GGC> GGT) within exon 11 of LMNA …
Lamin A, farnesylation and aging
S Reddy, L Comai - Experimental cell research, 2012 - Elsevier
Lamin A is a component of the nuclear envelope that is synthesized as a precursor prelamin
A molecule and then processed into mature lamin A through sequential steps of …
A molecule and then processed into mature lamin A through sequential steps of …
Progerin-induced replication stress facilitates premature senescence in Hutchinson-Gilford progeria syndrome
K Wheaton, D Campuzano, W Ma… - … and cellular biology, 2017 - Taylor & Francis
Hutchinson-Gilford progeria syndrome (HGPS) is caused by a mutation in LMNA that
produces an aberrant lamin A protein, progerin. The accumulation of progerin in HGPS cells …
produces an aberrant lamin A protein, progerin. The accumulation of progerin in HGPS cells …
Rapamycin reverses cellular phenotypes and enhances mutant protein clearance in Hutchinson-Gilford progeria syndrome cells
Hutchinson-Gilford progeria syndrome (HGPS) is a lethal genetic disorder characterized by
premature aging. HGPS is most commonly caused by a de novo single-nucleotide …
premature aging. HGPS is most commonly caused by a de novo single-nucleotide …
Are there common mechanisms between the Hutchinson–Gilford progeria syndrome and natural aging?
VV Ashapkin, LI Kutueva, SY Kurchashova… - Frontiers in …, 2019 - frontiersin.org
The Hutchinson–Gilford progeria syndrome (HGPS) is a premature aging disease caused by
mutations of the LMNA gene leading to increased production of a partially processed form of …
mutations of the LMNA gene leading to increased production of a partially processed form of …
Epigenetic involvement in Hutchinson-Gilford progeria syndrome: a mini-review
W Arancio, G Pizzolanti, SI Genovese, M Pitrone… - Gerontology, 2014 - karger.com
Hutchinson-Gilford progeria syndrome (HGPS) is a rare human genetic disease that leads to
a severe premature ageing phenotype, caused by mutations in the LMNA gene. The LMNA …
a severe premature ageing phenotype, caused by mutations in the LMNA gene. The LMNA …
Perturbation of wild‐type lamin A metabolism results in a progeroid phenotype
J Candelario, S Sudhakar, S Navarro, S Reddy… - Aging …, 2008 - Wiley Online Library
Mutations in the lamin A/C gene cause the rare genetic disorder Hutchinson–Gilford
progeria syndrome (HGPS). The prevalent mutation results in the production of a mutant …
progeria syndrome (HGPS). The prevalent mutation results in the production of a mutant …