Studies have reported reduced natural SARS-CoV-2 infection-and vaccine-induced
neutralization against omicron BA. 4/BA. 5 compared with earlier omicron subvariants. This …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron (B. 1.1. 529)
variant is highly transmissible with potential immune escape. We conducted a test-negative …

ABSTRACT Background Protection from SARS-CoV-2 vaccines wanes over time and is
compounded by emerging variants including Omicron subvariants. This study evaluated …

Immunity against Omicron Variants after Vaccine Boost After a third (booster) dose of SARS-
CoV-2 vaccine, immunity waned more slowly than after two doses and even more slowly in …

Abstract The SARS-CoV-2 Omicron variant has demonstrated enhanced transmissibility and
escape of vaccine-derived immunity. Although first-generation vaccines remain effective …

The large number of spike substitutions in Omicron lineage variants (BA. 1, BA. 1.1., and BA.
2) could jeopardize the efficacy of SARS-CoV-2 vaccines. We evaluated in mice the …

There is limited knowledge on durability of neutralization capacity and antibody affinity
maturation generated following two versus three doses of SARS-CoV-2 mRNA vaccines in …

Background The safety and immunogenicity of the bivalent omicron-containing mRNA-
1273.214 booster vaccine are not known. Methods In this ongoing, phase 2–3 study, we …

Importance In 2022, Omicron variants circulated globally, and Urumqi, China, experienced a
COVID-19 outbreak seeded by Omicron BA. 5 variants, resulting in the highest number of …

We previously presented day 29 interim safety and immunogenicity results from a phase 2/3
study (NCT04927065) comparing the Omicron-BA. 1-containing bivalent vaccine mRNA …