Despite improvements in cardiopulmonary resuscitation (CPR) quality, defibrillation
technologies, and implementation of therapeutic hypothermia, less than 10% of out-of …

Mitochondrial fission, regulated by dynamin-related protein-1 (Drp1), is a newly recognized
determinant of mitochondrial function, but its contribution to left ventricular (LV) impairment …

Mitochondrial fission is predominantly controlled by the activity of dynamin-related protein1
(Drp1), which has been reported to be involved in mitochondria apoptosis pathways …

Maintenance of mitochondrial function and integrity is critical for normal cell survival,
particularly in non-dividing cells with a high-energy demand such as cardiomyocytes. Well …

Mitochondria are highly dynamic organelles undergoing cycles of fusion and fission to
modulate their morphology, distribution, and function, which are referred as 'mitochondrial …

Most cell death stimuli trigger the mitochondrial release of cytochrome c and other cofactors
that induce caspase activation and ensuing apoptosis. Apoptosis is also associated with …

Mitochondria play a crucial role in multitude of cellular processes including energy
production, calcium signaling, and apoptosis. This remarkable organelle constantly …

Objectives: Survival following sudden cardiac arrest is poor despite advances in
cardiopulmonary resuscitation and the use of therapeutic hypothermia. Dynamin-related …

The constant physiological flux of mitochondrial fission and fusion is inextricably tied to the
maintenance of cellular bioenergetics and the fluidity of mitochondrial networks. Yet, the …

Abstract Dynamin-related protein 1 (Drp1) is a cytosolic GTPase protein that when activated
translocates to the mitochondria, meditating mitochondrial fission and increasing reactive …