Alzheimer's disease (AD) is characterised by Ap plaque formation, neuroinflammation and
neurodegeneration. Current therapies for AD do not modify disease progression therefore …

Joshua Keene, Britanny Alexis Granett, Emily Michelle Crombez, Yannick Marchalant,
Central Michigan University, Mount Pleasant, MI, USA. Contact e-mail: march1y@ cmich …

Inflammation has been argued to play a primary role in the pathogenesis of Alzheimer's
disease (AD). Lipopolysaccharide (LPS) activates the innate immune system, triggering …

The continuing failure to develop an effective treatment for Alzheimer's disease urges a
better understanding of the pathogenic mechanisms and the improvement of current animal …

Alzheimers disease (AD) is pathologically characterized by amyloid plaques, neurofibrillary
tangles, inflammation, and neurodegeneration. According to the amyloid hypothesis of AD …

One increasingly dominant hypothesis regarding the pathogenesis of Alzheimer dementia is
the inflammation hypothesis. In brief, this hypothesis argues that at least some of the …

Degeneration of locus ceruleus neurons and subsequent reduction of norepinephrine
concentration in locus ceruleus projection areas represent an early pathological indicator of …

Traumatic brain injury is a risk factor for Alzheimer's disease (AD), however the effect of such
neural damage on the onset and progression of beta-amyloid (Aβ) plaque pathology is not …

There is increasing evidence that links chronic activation of glial cells and the subsequent
self-propagating cycle of neuroinflammation to the neurodegenerative progression of …

Animal models of Alzheimer's disease (AD) which emphasize activation of microglia may
have particular utility in correlating proinflammatory activity with neurodegeneration. This …