Oxidative stress hypothesis in Alzheimer's disease

WR Markesbery - Free radical biology and medicine, 1997 - Elsevier
The major hurdle in understanding Alzheimer's disease (AD) is a lack of knowledge about
the etiology and pathogenesis of selective neuron death. In recent years, considerable data …

Oxidative stress signalling in Alzheimer's disease

X Zhu, AK Raina, H Lee, G Casadesus, MA Smith… - Brain research, 2004 - Elsevier
Multiple lines of evidence demonstrate that oxidative stress is an early event in Alzheimer's
disease (AD), occurring prior to cytopathology, and therefore may play a key pathogenic role …

Causes of oxidative stress in Alzheimer disease

X Zhu, B Su, X Wang, MA Smith, G Perry - Cellular and molecular life …, 2007 - Springer
Oxidative stress is one of the earliest events of Alzheimer disease (AD), with implications as
an important mediator in the onset, progression and pathogenesis of the disease. The …

Alzheimer's disease and oxidative stress: implications for novel therapeutic approaches

C Behl - Progress in neurobiology, 1999 - Elsevier
Alzheimer's disease (AD) is a progressive neurodegenerative disorder with a deadly
outcome. AD is the leading cause of senile dementia and although the pathogenesis of this …

Alzheimer s disease and oxidative stress: a review

M Pohanka - Current medicinal chemistry, 2014 - ingentaconnect.com
Alzheimer´ s disease (AD) is a neurodegenerative disorder with no known cure and rapid
rise in incidence. The predominant cognitive impairment is currently treated using cognitive …

Oxidative stress, synaptic dysfunction, and Alzheimer's disease

E Tönnies, E Trushina - Journal of Alzheimer's Disease, 2017 - content.iospress.com
Alzheimer's disease (AD) is a devastating neurodegenerative disorder without a cure. Most
AD cases are sporadic where age represents the greatest risk factor. Lack of understanding …

Oxidant/antioxidant imbalance and the risk of Alzheimer's disease

AE Abdel Moneim - Current Alzheimer Research, 2015 - ingentaconnect.com
Alzheimer's disease (AD) is the most common form of dementia characterized by
progressive loss of memory and other cognitive functions among older people. Senile …

Oxidative stress in Alzheimer's disease brain: new insights from redox proteomics

DA Butterfield, M Perluigi, R Sultana - European journal of pharmacology, 2006 - Elsevier
Alzheimer's disease, an age-related neurodegenerative disorder, is characterized clinically
by a progressive loss of memory and cognitive functions. Neuropathologically, Alzheimer's …

Comparative biology and pathology of oxidative stress in Alzheimer and other neurodegenerative diseases: beyond damage and response

G Perry, MA Taddeo, A Nunomura, X Zhu… - … and Physiology Part C …, 2002 - Elsevier
In this review, we consider comparative aspects of the biology and pathology of oxygen
radicals in neurodegenerative disease and how these findings have influenced our concept …

Oxidative stress in Alzheimer's disease: why did antioxidant therapy fail?

T Persson, BO Popescu… - Oxidative medicine and …, 2014 - Wiley Online Library
Alzheimer's disease (AD) is the most common form of dementia in the elderly, with
increasing prevalence and no disease‐modifying treatment available yet. A remarkable …