Alzheimer's disease (AD) is a neurodegenerative disease that is usually accompanied by
aging, increasingly being the most common cause of dementia in the elderly. This disorder …

Imbalances of oxidative homeostasis and lipid peroxidation have been revealed as
important factors involved in neurodegenerative disorders such as Alzheimer's disease. The …

Alzheimer disease is a common age-related neurodegenerative disease characterized
pathologically by senile plaques, neurofibrillary tangles, synaptic disruption, and …

Increasing evidence suggests that oxidative stress is intimately associated with Alzheimer
disease pathophysiology. Nucleic acids (nuclear DNA, mitochondrial DNA, and RNA) are …

Purpose: Since the description of his original patient Auguste D. with cognitive disability,
Alois Alzheimer persisted in his clinical investigations to understand this complex disease …

Oxidative stress has been implicated to play a crucial role in the pathogenesis of a number
of diseases, including neurodegenerative disorders, cancer, and ischemia, just to name a …

Increasing evidence demonstrates that oxidative stress causes damage to cell function with
aging and is involved in a number of age-related disorders including atherosclerosis, ar …

In less than a decade, beginning with the demonstration by Floyd, Stadtman, Markesbery et
al.[1] of increased reactive carbonyls in the brains of patients with Alzheimer's disease (AD) …

Alzheimer's disease (AD) is the most common form of neurodegenerative disorder with
dementia. In its sporadic form, AD results from the combination of genetic factors with …

Although iron is essential in maintaining the function of the central nervous system, it is a
potent source of reactive oxygen species. Excessive iron accumulation occurs in many …