Increasing numbers of individuals, particularly the elderly, suffer from neurodegenerative
disorders. These diseases are normally characterized by progressive loss of neuron cells …

The brain is a highly metabolically active organ producing large amounts of reactive oxygen
species (ROS). These ROS are kept in check by an elaborate network of antioxidants …

Alzheimer's disease (AD) is a multifactorial disorder characterized by the progressive
deterioration of neuronal networks. The primary cause and sequence of its progression are …

Neurologists have highly observed a frequent increasing number of elderly patients with
Alzheimer's disease (AD) without any relevant evidence of any genetic or known AD‐linked …

Biological tissues require oxygen to meet their energetic demands. However, the
consumption of oxygen also results in the generation of free radicals that may have …

Lipid peroxidation involves a cascade of reactions in which production of free radicals
occurs selectively in the lipid components of cellular membranes. Polyunsaturated fatty …

Alzheimer's disease (AD) is a progressive neurodegenerative disorder that is characterized
pathologically by the presence of senile plaques, neurofibrillary tangles, and synapse loss …

ANTIOXIDANTS & REDOX SIGNALING Volume 5, Number 5, 2003© Mary Ann Liebert, Inc.
free radicals (4, 13, 40). Iron-and copper-induced free radical damage may play a …

Simple Summary Alzheimer's disease (AD) is the most common neurodegenerative disease,
intensifying impairments in cognition, behavior, and memory. Histopathological AD …

The high energy demand of the brain renders it sensitive to changes in energy fuel supply
and mitochondrial function. Deficits in glucose availability and mitochondrial function are …