In all organisms, RNA-binding proteins participate in modulating all the steps in the life cycle
of RNA, including transcription, folding, translation and turnover. In bacteria, RNA-binding …

Over the past years, small non-coding RNAs (sRNAs) emerged as important modulators of
gene expression in bacteria. Guided by partial sequence complementarity, these sRNAs …

Abstract The Sm-protein Hfq facilitates interactions between small non-coding RNA (sRNA)
and target mRNAs. In enteric Gram-negative bacteria, Hfq is required for sRNA regulation …

The RNA chaperone Hfq is a key player in small RNA (sRNA)-mediated regulation of target
mRNAs in many bacteria. The absence of this protein causes pleiotropic phenotypes such …

Hfq is an RNA-binding protein that participates in the regulatory activity of small non-coding
RNAs (sRNAs) in many species of bacteria. Hfq protein was first crystallized from …

To regulate stress responses and virulence, bacteria use small regulatory RNAs (sRNAs).
These RNAs can up or down regulate target mRNAs through base pairing by influencing …

Most of the sequenced bacterial genomes contain a gene encoding a protein known as Hfq
that resembles the eukaryotic RNA-binding proteins of the LSm family. It was originally …

Hfq, a protein required for small RNA (sRNA)-mediated regulation in bacteria, binds RNA
with low-nanomolar Kd values and long half-lives of complexes (> 100 min). This cannot be …

The homohexameric (L) Sm protein Hfq is a central mediator of small RNA-based gene
regulation in bacteria. Hfq recognizes small regulatory RNAs (sRNAs) specifically, despite …

Highlights•Novel cross-linking and sequencing methods uncover new sRNAs and sRNA
networks.•Many sRNAs are encoded within the 3′ and 5′ UTRs of mRNA as well as …