ABSTRACT A live attenuated bovine parainfluenza virus type 3 (PIV3), harboring the fusion
(F) and hemagglutinin-neuraminidase (HN) genes of human PIV3, was used as a virus …

Human metapneumovirus (hMPV) infection causes respiratory tract disease similar to that
observed during human respiratory syncytial virus infection (hRSV). hMPV infections have …

Recombinant bovine/human parainfluenza virus type 3 (rB/HPIV3), a recombinant bovine
PIV3 (rBPIV3) in which the F and HN genes were replaced with their HPIV3 counterparts …

Bovine parainfluenza virus type 3 (bPIV3) is being evaluated as an intranasal vaccine for
protection against human PIV3 (hPIV3). In young infants, the bPIV3 vaccine appears to be …

Parainfluenza virus type 3 (PIV3) and respiratory syncytial virus (RSV) are the main causes
of ubiquitous acute respiratory diseases of infancy and early childhood, causing 20–25% of …

We sought to develop a live attenuated parainfluenza virus type 2 (PIV2) vaccine strain for
use in infants and young children, using reverse genetic techniques that previously were …

The chimeric recombinant virus rHPIV3-NB, a version of human parainfluenza virus type 3
(HPIV3) that is attenuated due to the presence of the bovine PIV3 nucleocapsid (N) protein …

Human parainfluenza virus type 1 (HPIV1) is a significant cause of respiratory tract disease
in infants and young children for which a vaccine is needed. In the present study, we sought …

Reverse genetics was used to develop a two-component, trivalent live attenuated vaccine
against human parainfluenza virus type 3 (HPIV3) and respiratory syncytial virus (RSV) …

Respiratory syncytial virus (RSV) causes respiratory disease in young children, the elderly,
and immunocompromised individuals, often resulting in hospitalization and/or death. After …