Discoveries leading to an improved understanding of immune surveillance of the central
nervous system (CNS) have repeatedly provoked dismissal of the existence of immune …

Immune privilege of the central nervous system (CNS) has been ascribed to the presence of
a blood–brain barrier and the lack of lymphatic vessels within the CNS parenchyma …

The central nervous system (CNS) is considered to be an immunological privileged site.
However, inflammatory reactions in response to virus infections, in multiple sclerosis (MS) …

At steady state, the CNS parenchyma has few to no lymphocytes and less potent Ag-
presentation capability compared with other organs. However, the meninges surrounding …

The recent (re) discovery of the meningeal lymphatic system has opened new theories as to
how immune cells traffic and interact with the central nervous system (CNS). While evidence …

Neuroinflammatory diseases, such as multiple sclerosis, are characterized by invasion of the
brain by autoreactive T cells. The mechanism for how T cells acquire their encephalitogenic …

Meningeal lymphatics near the cribriform plate undergo lymphangiogenesis during
neuroinflammation to drain excess fluid. Here, we hypothesized that lymphangiogenic …

The cardinal dogma of central nervous system (CNS) immunology believed brain is an
immune privileged site, but scientific evidences gathered so far have overturned this notion …

Whereas the study of the interactions between the immune system and the central nervous
system (CNS) has often focused on pathological conditions, the importance of neuroimmune …

There are no conventional lymphatic vessels within the CNS parenchyma, although it has
been hypothesized that lymphatics near the cribriform plate or dura maintain fluid …