There are no conventional lymphatic vessels within the CNS parenchyma, although it has
been hypothesized that lymphatics near the cribriform plate or dura maintain fluid …

Recent discoveries of the glymphatic system and of meningeal lymphatic vessels have
generated a lot of excitement, along with some degree of skepticism. Here, we summarize …

The CNS is an immune-privileged environment, yet the local control of multiple pathogens is
dependent on the ability of immune cells to access and operate within this site. However …

In most organs of the body, immunological reactions involve the drainage of antigens and
antigen presenting cells (APCs) along defined lymphatic channels to regional lymph nodes …

The central nervous system (CNS) has historically been viewed as an immunologically
privileged site, but recent studies have uncovered a vast landscape of immune cells that …

The central nervous system (CNS) is an immunologically privileged site to which access of
circulating immune cells is tightly controlled by the endothelial blood–brain barrier (BBB; see …

Dear Editor, Two recent papers (Aspelund et al. 2015; Louveau et al. 2015) reported the
presence in mice of lymphatics in the cerebral dura mater, the most external of the …

Rapid progress is being made in understanding the roles of the cerebral meninges in the
maintenance of normal brain function, in immune surveillance, and as a site of disease. Most …

A genuine and functional lymphatic vascular system is found in the meninges that sheath the
central nervous system (CNS). This unexpected (re) discovery led to a reevaluation of CNS …

Immune cells enter the central nervous system (CNS) from the circulation under normal
conditions for immunosurveillance and in inflammatory neurologic diseases. This review …