Extensive survey of meiotic metaphase II arrest during oocyte maturation in vertebrates
revealed that the mitogen-activated protein kinase (MAPK) pathway regulated by the c-mos …

Mitogen-activated protein kinase (MAPK) is one of the protein kinases activated during
meiotic maturation of Xenopus laevis oocytes. The c-Mosxe protein kinase, which has been …

Mos and the mitogen-activated protein kinase (MAPK) cascade have been established as
crucial regulators of second meiotic metaphase arrest, the so-called CSF arrest, in …

Abstract The ERK1/ERK2 MAP kinases (MAPKs) are transiently activated during mitosis,
and MAPK activation has been implicated in the spindle assembly checkpoint and in …

Mammalian eggs are arrested in metaphase II of meiosis until fertilization. Arrest is
maintained by cytostatic factor (CSF) activity, which is dependent on the MOS–MEK–MAPK …

The c-Mos serine/threonine protein kinase is an essential component of cytostatic factor
(CSF), which is required for metaphase II arrest of eggs in vertebrates. Previously, we …

Unfertilized frog eggs arrest at the second meiotic metaphase, due to cytostatic activity of the
c-mos proto-oncogene (CSF). MAP kinase has been proposed to mediate CSF activity in …

Oocytes of most vertebrates arrest at metaphase of the second meiosis (meta-II) to await
fertilization, thus preventing parthenogenetic activation. This arrest is caused by a …

Mos plays a crucial role in meiotic cell division in vertebrates. In Xenopus, Mos is involved in
the initiation of oocyte maturation as an initiator and in the arrest at the metaphase II stage …

The mos proto-oncogene-encoded serine/threonine protein kinase plays a key cell cycle-
regulatory role during meiosis. The Mos protein is required for the activation and …