Doxorubicin and other anthracycline compounds exert their anti-cancer effects by causing
DNA damage and initiating cell cycle arrest in cancer cells, followed by apoptosis. DNA …

Abstract BH3 (Bcl-2 homology 3)-only proteins of the Bcl-2 family play an essentialrole in
apoptosis. In this study, a novel human BH3-only protein, Bcl-2-interacting mediator (Bim) γ …

We previously demonstrated that Bim is the main BH3-only protein replacing Bak/Bax from
Bcl-xl to activate apoptosis in a p53-independent manner in response to doxorubicin in …

BH3-only protein Bim is a critical regulator of apoptosis and plays an essential role in
mammalian development, but the characterization of Bim and its isoforms in hepatocellular …

Paclitaxel (Taxol)-induced cell death requires the intrinsic cell death pathway, but the
specific participants and the precise mechanisms are poorly understood. Previous studies …

The chemotherapeutic drug, paclitaxel, induces mitotic arrest and then activates the cellular
apoptotic program. Although paclitaxel has been in clinical use for over 10 years for the …

A significant variation in susceptibility to paclitaxel-mediated killing was observed among a
panel of short-term cultured non-small-cell lung cancer (NSCLC) cell lines. Susceptibility to …

For past two decades, p53 has been claimed as the primary sensor initiating apoptosis.
Under severe cellular stress, p53 transcriptional activity activates BH3-only proteins such as …

BH3-only proteins constitute major proportion of pro-apoptotic members of B-cell lymphoma
2 (Bcl-2) family of apoptotic regulatory proteins and participate in embryonic development …

Defective apoptosis not only promotes tumorigenesis, but also can confound
chemotherapeutic response. Here we demonstrate that the proapoptotic BH3-only protein …