This review highlights potential molecular targets for treating neuropathic orofacial pain
based on current findings in animal models. Preclinical research is currently elucidating the …

Trigeminal nerve injury is known to cause severe persistent pain in the orofacial region. This
pain is difficult to diagnose and treat. Recently, many animal studies have reported that …

Painful traumatic trigeminal neuropathy (PTTN) may occur following major craniofacial or
oral trauma, or may be subsequent to relatively minor dental interventions. Following injury …

While physiological pain (nociceptive pain) has a protective role in warning of potential
tissue damage in response to a variety of noxious stimuli, pathological pain (neuropathic …

Trigeminal neuralgia (TN) is a complex orofacial pain syndrome characterized by the
paroxysmal onset of pain attacks in the trigeminal distribution. The underlying mechanism …

Orofacial neuropathic pain is initiated by extraction of teeth or nerve injury from trauma in the
trigeminal nerve that innervates the facial area. In the experiment, orofacial neuropathic pain …

Trigeminal nerve injury is one of the causes of chronic orofacial pain. Patients suffering from
this condition have a significantly reduced quality of life. The currently available …

Objective This review aims to systematically summarize the methods of establishing various
models of trigeminal neuralgia (TN), the scope of application, and current animals used in …

Trigeminal neuralgia (TN) is an episodic facial pain which feels like an electric shock of
unilateral origin. This neuropathic disorder is an intensely stressful to bear for patient and …

Neuropathic pain in the orofacial region is the clinical manifestation of trigeminal nerve
injury following oral surgeries such as tooth extraction, dental implantation or tooth pulp …