This review aims at characterising the process of male germ cell death, focusing on the role
of testicular steroid hormones, the role of two important induction pathways of apoptosis, the …

Spermatogenesis is a complex process of male germ cell proliferation and maturation from
spermatogonia to spermatozoa. During this process, the number of germ cells has to match …

Loss of germ cells is very common during various stages of mammalian spermatogenesis.
Although cell death, particularly apoptosis, has been implicated, our understanding of the …

Onset of spermatogenesis is associated with an apoptosis wave that limits its efficiency
during the first cycles in most mammals. Beyond the first cycles the actual efficiency of …

Spermatogenesis is a dynamic process in which stem spermatogonia through a series of
events become mature spermatozoa. Not all germ cells achieve maturity and cell death by …

Elimination of germ cells via apoptosis occurs spontaneously under normal physiologic
conditions and is often heightened after chemical-induced testicular injury. Though many …

Germ cell apoptosis is very common during various stages of mammalian testicular
development. However, our understanding of the mechanisms underlying male germ cell …

A growing body of evidence demonstrates that germ cell death both spontaneous (during
normal spermatogenesis) and that induced by suppression of hormonal support or …

From the viewpoint of improving germ cell production and treatment of testicular cancers,
understanding the control of testicular cell death is of great relevance. One of the prominent …

During early development, apoptosis plays a major role in the ontogeny of the germ line as a
means of regulating the germ cell: Sertoli cell ratio. In the adult, apoptosis fulfils another …