Islets produce a variety of cytokines and chemokines in response to physiologic and
pathologic stimulation by nutrients. The cellular source of these inflammatory mediators …

A common feature of the two major forms of human diabetes is the partial or complete loss of
insulin secretion from β-cells in the pancreatic islets of Langerhans. In this article, we review …

Our studies of mice deficient for the E2F1 and E2F2 transcription factors have revealed
essential roles for these proteins in the cell cycle control of pancreatic exocrine cells and the …

In view of the recent success in pancreatic islet transplantation, interest in treating diabetes
by the delivery of insulin-producing β-cells has been renewed. Because differentiated …

For the past century, insulin injections have saved millions of lives, but glycemic instability is
still a persistent challenge for people with diabetes, leading to tremendous morbidity and …

Pancreatic islet β cells are organized in rosette-like structures around blood vessels and
exhibit an artery-to-vein orientation, but they do not display the typical epithelial polarity. It is …

Interactions between the endocrine cells in islets of Langerhans influence their secretory
function, and disruption of islet structure results in impaired insulin secretory responses to …

Diabetes mellitus is a devastating disease and over 6% of the population is affected
worldwide. The success achieved over the last few years with islet transplantation suggest …

β-cell replacement represents the ultimate cure for type 1 diabetes, however it is limited by
availability of organ donors. Adult human islets are difficult to propagate in culture, and …

Islet transplantation is a treatment for selected adults with type 1 diabetes and severe
hypoglycemia. Islets from two or more donor pancreases, a scarce resource, are usually …