Nitric oxide (NO) is a ubiquitous, naturally occurring molecule found in a variety of cell types
and organ systems. In the cardiovascular system, NO is an important determinant of basal …

Nitric oxide (NO) is a ubiquitous signaling molecule that regulates various cellular
physiological and pathological events in virtually all vital organs. The synthesis of NO is …

Many acute and chronic diseases of the cardiovascular system are characterised by an
inflammatory response. Atherogenesis is considered a chronic inflammatory dis-ease of the …

The role of nitric oxide synthase 1 (NOS1) as a major modulator of cardiac function has been
extensively studied in experimental models; however, its role in human ischemic …

Background: The role of the nitric oxide synthase (NOS) system in cardiac architecture and
function remains unknown. This point was addressed in mice that lack all 3 NOS genes …

Nitric oxide synthase (NOS) isoforms are discovered in an increasing variety of cell types
with different roles in signaling. The inducible NOS (ie iNOS or NOS II) is expressed in …

NO is a free radical gas, NO•, in equilibrium with the closely related redox forms NOJ and
NO+. With a molecular weight of only 30 Da/mol (for reference, molecular oxygen is 32 …

During the last decade, the effects of nitric oxide (NO) on contractile function of failing
myocardium elicited a lot of interest and research activity. Because of initial reports of NO …

The modulatory role of endothelial nitric oxide synthase (eNOS) on heart contraction,
relaxation and rate is examined in light of recent studies using genetic deletion or …

The mechanisms by which nitric oxide (NO) influences myocardial Ca2+ cycling remain
controversial. Because NO synthases (NOS) have specific spatial localization in cardiac …