Poststroke cognitive impairment (PSCI) often occurs during the stroke recovery period and
greatly increases the difficulty of rehabilitation. Activation of neuroinflammation and long …

Expression of Bcl2 family genes was studied during the early phase of long-term
potentiation in the CA1 field of rat hippocampal slices. The level of Bax mRNA and protein …

By virtue of its capacity to prevent apoptosis the proto-oncogene bcl-2 is believed to play a
crucial role in CNS development. Studies in rodents have shown that the anti-apoptosis Bcl …

Stress may predispose individuals toward depression through down-regulation of
neurogenesis and increase in apoptosis in the brain. However, many subjects show high …

Due to the functional importance of Bcl-2, which acts as an anti-apoptotic protein that also
affects neural differentiation and adult neurogenesis, we undertook a detailed …

Time-course expression of Bax and Bcl-2 proteins, identified as apoptosis-regulating
molecules, was assessed in gerbil hippocampus following transient forebrain ischemia …

The proto-oncogene bcl-2 can rescue cells from apoptosis and necrosis and its mechanism
of action may involve antioxidant activity. The possible involvement of free radicals in …

Principal mental disorders affecting the geriatric population include dementia and
depression. A lack of trophic support is thought to contribute to the pathology of these …

THE present study addressed the hypothesis that the neuronal mineralocorticoid receptor
(MR) regulates genes associated with cell death, such as bax and p53, and cell viability …

Overexpression of bcl‐2protects neurons from numerous necrotic insults, both in vitro and in
vivo. While the bulk of such protection is thought to arise from Bcl‐2 blocking cytochrome c …