Tocilizumab for treatment of severe COVID-19 patients: preliminary results from SMAtteo COvid19 REgistry (SMACORE)

M Colaneri, L Bogliolo, P Valsecchi, P Sacchi… - Microorganisms, 2020 - mdpi.com
Objective: This study aimed to assess the role of Tocilizumab therapy (TCZ) in terms of ICU
admission and mortality rate of critically ill patients with severe COVID-19 pneumonia …

Clinical consequences for individuals treated with tocilizumab for serious COVID-19 Infection

ASI Rabie, H Salah, ASA Said, AH Shaaban… - Healthcare, 2023 - mdpi.com
There seem to currently be no therapeutic medications found for the severe coronavirus
infection in 2019 (COVID-19). In light of this, it has been hypothesized that the …

Tocilizumab in COVID-19: a meta-analysis, trial sequential analysis, and meta-regression of randomized-controlled trials

TAC Snow, N Saleem, G Ambler, E Nastouli… - Intensive Care …, 2021 - Springer
Abstract Purpose Interleukin-6 (IL-6) levels discriminate between patients with mild and
severe COVID-19, making IL-6 inhibition an attractive therapeutic strategy. We conducted a …

Timely administration of tocilizumab improves outcome of hospitalized COVID-19 patients

A Rutgers, PE Westerweel, B van der Holt, S Postma… - Plos one, 2022 - journals.plos.org
Introduction The aim of this study was to determine the efficacy of early tocilizumab treatment
for hospitalized patients with COVID-19 disease. Methods Open-label randomized phase II …

[HTML][HTML] Tocilizumab for treatment of patients with severe COVID–19: A retrospective cohort study

T Kewan, F Covut, MJ Al–Jaghbeer, L Rose… - …, 2020 - thelancet.com
Background Tocilizumab was approved for chimeric antigen receptor T–cell therapy induced
cytokine release syndrome and it may provide clinical benefit for selected COVID–19 …

Clinical characteristics and early outcomes in patients with COVID-19 treated with tocilizumab at a United States academic center

CA Rimland, CE Morgan, GJ Bell, MK Kim, T Hedrick… - Medrxiv, 2020 - medrxiv.org
Limited evidence is available to guide treatment of coronavirus disease 2019 (COVID-19),
caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). A …

Tocilizumab in hospitalized patients with COVID‐19: clinical outcomes, inflammatory marker kinetics, and safety

JA Hill, MP Menon, S Dhanireddy… - Journal of medical …, 2021 - Wiley Online Library
Abstract Coronavirus disease 2019 (COVID‐19) due to infection with severe acute
respiratory syndrome coronavirus 2 causes substantial morbidity. Tocilizumab, an …

Tocilizumab treatment for COVID-19 patients: a systematic review and meta-analysis

Q Wei, H Lin, RG Wei, N Chen, F He, DH Zou… - Infectious diseases of …, 2021 - Springer
Abstract Background Coronavirus disease 2019 (COVID-19) has killed over 2.5 million
people worldwide, but effective care and therapy have yet to be discovered. We conducted …

Effect of tocilizumab on clinical outcomes at 15 days in patients with severe or critical coronavirus disease 2019: randomised controlled trial

VC Veiga, JAGG Prats, DLC Farias, RG Rosa… - bmj, 2021 - bmj.com
Objective To determine whether tocilizumab improves clinical outcomes for patients with
severe or critical coronavirus disease 2019 (covid-19). Design Randomised, open label trial …

Tocilizumab improves 28-day survival in hospitalized patients with severe COVID-19: an open label, prospective study

T Karampitsakos, E Malakounidou, O Papaioannou… - Respiratory …, 2021 - Springer
Background Data on the safety and efficacy profile of tocilizumab in patients with severe
COVID-19 needs to be enriched. Methods In this open label, prospective study, we …