Tocilizumab treatment for COVID-19 patients: a systematic review and meta-analysis

Q Wei, H Lin, RG Wei, N Chen, F He, DH Zou… - Infectious diseases of …, 2021 - Springer
Abstract Background Coronavirus disease 2019 (COVID-19) has killed over 2.5 million
people worldwide, but effective care and therapy have yet to be discovered. We conducted …

Effect of tocilizumab in hospitalized patients with severe pneumonia COVID-19: a cohort study

B Rossi, LS Nguyen, P Zimmermann, F Boucenna… - medRxiv, 2020 - medrxiv.org
Background Tocilizumab, a drug targeting interleukin-6 administrated in the right timeframe
may be beneficial in coronavirus-disease-2019 (COVID-19). We aimed to assess its benefit …

Effects of tocilizumab on adults with COVID-19 pneumonia: A meta-analysis

CC Chen, YP Yang, HL Tsai, TH Tung - Frontiers in Medicine, 2022 - frontiersin.org
Background Coronavirus disease-2019 (COVID-19), a worldwide disaster, has already
affected lots of people. Effective care and therapy are currently being evaluated in full swing …

Beneficial and harmful outcomes of tocilizumab in severe COVID‐19: a systematic review and meta‐analysis

M Rubio‐Rivas, CG Forero… - … : The Journal of …, 2021 - Wiley Online Library
Introduction The results of studies of tocilizumab (TCZ) in COVID‐19 are contradictory. Our
study aims to update medical evidence from controlled observational studies and …

Tocilizumab in patients with severe COVID-19: a retrospective cohort study

G Guaraldi, M Meschiari, A Cozzi-Lepri… - The Lancet …, 2020 - thelancet.com
Background No therapy is approved for COVID-19 pneumonia. The aim of this study was to
assess the role of tocilizumab in reducing the risk of invasive mechanical ventilation and …

[HTML][HTML] Tocilizumab treatment in critically ill patients with COVID-19: A retrospective observational study

E Huang, S Isonaka, H Yang, E Salce… - International Journal of …, 2021 - Elsevier
Objective Elevated levels of pro-inflammatory cytokines are observed in severe COVID-19
infections, and cytokine storm is associated with disease severity. Tocilizumab, an …

Outcomes in patients with severe COVID-19 disease treated with tocilizumab: a case–controlled study

G Rojas-Marte, M Khalid, O Mukhtar… - … Journal of Medicine, 2020 - academic.oup.com
Background COVID-19 is an ongoing threat to society. Patients who develop the most
severe forms of the disease have high mortality. The interleukin-6 inhibitor tocilizumab has …

Effectiveness of tocilizumab in the treatment of hospitalized adults COVID-19: A systematic review and meta-analysis

J Zhang, C Chen, Y Yang, J Yang - Medicine, 2022 - journals.lww.com
Background: Since December 2019, the coronavirus disease (COVID-19) has spread
worldwide, leading to a global health threat. This study aimed to investigate the …

Does tocilizumab have an effect on the clinical outcomes in COVID-19 patients? A meta-analysis of randomized control trials

F Ghaempanah, M Nikouei, M Cheraghi… - … Policy and Practice, 2023 - Taylor & Francis
Background This meta-analysis was conducted to investigate the impact of tocilizumab on
clinical outcomes associated with COVID-19. Methods A comprehensive search was …

COVIDOSE: Low-dose tocilizumab in the treatment of Covid-19

GW Strohbehn, BL Heiss, SJ Rouhani, JA Trujillo, J Yu… - medRxiv, 2020 - medrxiv.org
Background Interleukin-6 (IL-6)-mediated hyperinflammation may contribute to the high
mortality of coronavirus disease 2019 (Covid-19). Tocilizumab, an IL-6 receptor blocking …