The effect of tocilizumab on COVID-19 patient mortality: A systematic review and meta-analysis of randomized controlled trials

WT Lin, SH Hung, CC Lai, CY Wang… - International …, 2021 - Elsevier
Objectives This systematic review and meta-analysis of randomized controlled trials (RCTs)
aimed to investigate the clinical efficacy and safety of tocilizumab for treating patients with …

Compassionate use of tocilizumab for treatment of SARS-CoV-2 pneumonia

SC Jordan, P Zakowski, HP Tran… - Clinical Infectious …, 2020 - academic.oup.com
Background Preliminary data from severe acute respiratory syndrome coronavirus 2 (SARS-
CoV-2) pneumonia patients indicate that a cytokine storm may increase morbidity and …

Tocilizumab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

DJ Dhasmana… - …, 2021 - research-repository.st-andrews.ac …
Background: In this study, we aimed to evaluate the effects of tocilizumab in adult patients
admitted to hospital with COVID-19 with both hypoxia and systemic inflammation. Methods …

Tocilizumab in patients with severe COVID‐19: A single‐center observational analysis

JP Knorr, V Colomy, CM Mauriello… - Journal of Medical …, 2020 - Wiley Online Library
Patients with coronavirus disease 2019 (COVID‐19) may develop severe respiratory
distress, thought to be mediated by cytokine release. Elevated proinflammatory markers …

[HTML][HTML] Tocilizumab for Covid-19—the ongoing search for effective therapies

E Huang, SC Jordan - New England Journal of Medicine, 2020 - Mass Medical Soc
Nearly 10 months after the identification of severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) as the virus responsible for coronavirus disease 2019 (Covid-19) …

[HTML][HTML] Repurposed tocilizumab in patients with severe COVID-19

J Tian, M Zhang, M Jin, F Zhang, Q Chu… - The Journal of …, 2021 - journals.aai.org
The coronavirus disease 2019 (COVID-19) has caused a global pandemic, resulting in
considerable morbidity and mortality. Tocilizumab, an inhibitor of IL-6, has been widely …

Efficacy of tocilizumab in the treatment of COVID‐19: An umbrella review

MM Rezaei Tolzali, M Noori, P Shokri… - Reviews in Medical …, 2022 - Wiley Online Library
Tocilizumab is an interleukin (IL)‐6 receptor inhibitor that has been proposed as a
therapeutic agent for treating coronavirus disease 2019 (COVID‐19). The aim of this …

[HTML][HTML] Effects of tocilizumab on mortality in hospitalized patients with COVID-19: a multicentre cohort study

J Martínez-Sanz, A Muriel, R Ron, S Herrera… - Clinical Microbiology …, 2021 - Elsevier
Objectives Tocilizumab has been proposed as a candidate therapy for patients with severe
coronavirus disease 2019 (COVID-19), especially among those with higher systemic …

[HTML][HTML] Efficacy and harms of tocilizumab for the treatment of COVID-19 patients: A systematic review and meta-analysis

A Piscoya, A Parra del Riego, R Cerna-Viacava… - PLoS …, 2022 - journals.plos.org
Introduction We systematically assessed benefits and harms of tocilizumab (TCZ), which is
an antibody blocking IL-6 receptors, in hospitalized COVID-19 patients. Methods Five …

Promising effects of tocilizumab in COVID-19: a non-controlled, prospective clinical trial

F Dastan, A Saffaei, S Haseli, M Marjani… - International …, 2020 - Elsevier
Background The clinical presentation of SARS-CoV-2 infection ranges from mild symptoms
to severe complications, including acute respiratory distress syndrome. In this syndrome …