Recently,(R)-1, 2-dimethyl-6, 7-dihydroxy-1, 2, 3, 4-tetrahydroisoquinoline [N-methyl-(R)
salsolinol, NM (R) Sal] and 1, 2-dimethyl-6, 7-dihydroxyisoquinolinium ion [DiMeDHIQ+] …

Summary 1 (R), 2 (N)-Dimethyl-6, 7-dihydroxy-l, 2, 3, 4-tetrahydroisoquinoline, N-methyl (R)
salsolinol, is a potent dopaminergic neurotoxin to induce parkinsonism in rats. The …

The effects of derivatives of dopamine‐derived isoquinoline,(R)‐1‐methyl‐6, 7‐dihydroxy‐1,
2, 3, 4‐tetrahydroisoquinoline [or (R)‐salsolinol] on hydroxyl radical production were studied …

Dopamine-derived 1-methyl-6, 7-dihydroxy-1, 2, 3, 4-tetrahydroisoquinoline (salsolinol, Sal)
and related compounds were examined for their selective neurotoxicity to dopamine …

Publisher Summary This chapter presents data on the metabolism of salsolinol in the brain
and discusses the possible involvement of salsolinol metabolism in induced cytotoxicity. The …

N-Methyl (R) salsolinol was found to be an endogenous dopaminergic neurotoxin inducing
parkinsonism in rodents and to increase in the cerebrospinal fluid of parkinsonian patients …

A dopamine-derived neurotoxin, 1 (R), 2 (N)-dimethyl-6, 7-dihydroxy-1, 2, 3, 4-
tetrahydroisoquinoline [N-methyl (R) salsolinol] was found to cause parkinsonian in rats and …

Salsolinol, 1-methyl-6, 7-dihydroxy-1, 2, 3, 4-tetrahydroisoquinoline, is an endogenous
catechol isoquinoline detected in humans by M. Sandler. In human brain, a series of …

Summary A dopamine-derived 1 (R), 2 (N)-dimethyl-6, 7-dihydroxy-1, 2, 3, 4-
tetrahydrosioquinoline [N-methyl-(R) salsolinol] was found to occur enantio-selectively in …

Various investigators address an augmented synthesis of tetrahydroisoquinolines, such as
salsolinol (SAL), or an increased N-methylation of these compounds as putative …