Characterization and mapping of DNA damage induced by reactive metabolites of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) at nucleotide resolution in …
JF Cloutier, R Drouin, M Weinfeld, TR O'Connor… - Journal of Molecular …, 2001 - Elsevier
The nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is an important
tobacco-specific carcinogen associated with lung cancer. Its complex enzymatic activation …
tobacco-specific carcinogen associated with lung cancer. Its complex enzymatic activation …
Identification of more than 100 structurally unique DNA-phosphate adducts formed during rat lung carcinogenesis by the tobacco-specific nitrosamine 4 …
Abstract The tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone
(NNK) is a powerful lung carcinogen in animal models and is considered a causative factor …
(NNK) is a powerful lung carcinogen in animal models and is considered a causative factor …
Comprehensive high-resolution mass spectrometric analysis of DNA phosphate adducts formed by the tobacco-specific lung carcinogen 4-(methylnitrosamino)-1-(3 …
The tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK, 1) is
a potent lung carcinogen in laboratory animals and is believed to play a key role in the …
a potent lung carcinogen in laboratory animals and is believed to play a key role in the …
Liquid chromatography-tandem mass spectrometry for the quantification of tobacco-specific nitrosamine-induced DNA adducts in mammalian cells
Quantification of DNA lesions constitutes one of the main tasks in toxicology and in
assessing health risks accompanied by exposure to carcinogens. Tobacco-specific …
assessing health risks accompanied by exposure to carcinogens. Tobacco-specific …
The Pyridyloxobutyl DNA Adduct, O6-[4-Oxo-4-(3-pyridyl)butyl]guanine, Is Detected in Tissues from 4-(Methylnitrosamino)- 1-(3-pyridyl)-1-butanone-treated A/J Mice
NM Thomson, PM Kenney… - Chemical research in …, 2003 - ACS Publications
The tobacco-specific nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), is
a potent pulmonary carcinogen. This unsymmetric nitrosamine can be metabolically …
a potent pulmonary carcinogen. This unsymmetric nitrosamine can be metabolically …
Context matters: contribution of specific DNA adducts to the genotoxic properties of the tobacco-specific nitrosamine NNK
LA Peterson - Chemical research in toxicology, 2017 - ACS Publications
The tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is a
potent pulmonary carcinogen in laboratory animals. It is classified as a Group 1 human …
potent pulmonary carcinogen in laboratory animals. It is classified as a Group 1 human …
K-ras Gene Sequence Effects on the Formation of 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)−DNA Adducts
R Ziegel, A Shallop, R Jones… - Chemical research in …, 2003 - ACS Publications
The tobacco specific pulmonary carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone
(NNK) is metabolically activated to electrophilic species that form methyl and pyridyloxobutyl …
(NNK) is metabolically activated to electrophilic species that form methyl and pyridyloxobutyl …
Quantitation of pyridyloxobutyl DNA adducts of tobacco-specific nitrosamines in rat tissue DNA by high-performance liquid chromatography− electrospray ionization …
Y Lao, PW Villalta, SJ Sturla, M Wang… - Chemical research in …, 2006 - ACS Publications
The tobacco-specific nitrosamines N '-nitrosonornicotine (NNN, 1) and 4-
(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK, 2) are potent carcinogens in rodents …
(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK, 2) are potent carcinogens in rodents …
Stable Isotope Labeling−Mass Spectrometry Analysis of Methyl- and Pyridyloxobutyl-Guanine Adducts of 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone in p53 …
The p53 tumor suppressor gene is a primary target in smoking-induced lung cancer.
Interestingly, p53 mutations observed in lung tumors of smokers are concentrated at …
Interestingly, p53 mutations observed in lung tumors of smokers are concentrated at …
Low Fidelity Bypass of O2-(3-Pyridyl)-4-oxobutylthymine, the Most Persistent Bulky Adduct Produced by the Tobacco Specific Nitrosamine 4-(Methylnitrosamino)-1-(3 …
ASP Gowda, G Krishnegowda, Z Suo… - Chemical research in …, 2012 - ACS Publications
4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is one of the most important human
carcinogens. It is metabolized to produce a variety of methyl and 4-(3-pyridyl)-4-oxo-butyl …
carcinogens. It is metabolized to produce a variety of methyl and 4-(3-pyridyl)-4-oxo-butyl …