Development of a quantitative liquid chromatography/electrospray mass spectrometric assay for a mutagenic tobacco specific nitrosamine-derived DNA adduct, O 6-[4 …
NM Thomson, RS Mijal, R Ziegel… - Chemical research in …, 2004 - ACS Publications
Liquid chromatography with electrospray tandem mass spectrometry (LC/ESI-MS/MS) was
employed to quantify O 6-[4-oxo-4-(3-pyridyl) butyl]-2 '-deoxyguanosine (O 6-pobdG), a …
employed to quantify O 6-[4-oxo-4-(3-pyridyl) butyl]-2 '-deoxyguanosine (O 6-pobdG), a …
Metabolism and DNA single strand breaks induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and its analogues in primary culture of rat hepatocytes
L Liu, MA Alaoui-Jamali, N El Alami, A Castonguay - Cancer research, 1990 - AACR
Previous studies have shown that the tobacco specific nitrosamine, 4-(methylnitrosamino)-1-
(3-pyridyl)-1-butanone (NNK), is hepatocarcinogenic and results in alkylation of hepatic …
(3-pyridyl)-1-butanone (NNK), is hepatocarcinogenic and results in alkylation of hepatic …
Identification of adducts produced by the reaction of 4-(acetoxymethylnitrosamino)-1-(3-pyridyl)-1-butanol with deoxyguanosine and DNA
P Upadhyaya, SJ Sturla, N Tretyakova… - Chemical research in …, 2003 - ACS Publications
4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) is a metabolite of the tobacco specific
carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). NNAL is present in the …
carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). NNAL is present in the …
γ-H2AX is a sensitive marker of DNA damage induced by metabolically activated 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone
Y Ibuki, M Shikata, T Toyooka - Toxicology in Vitro, 2015 - Elsevier
(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), a nicotine-derived nitrosamine, is a
potent pulmonary carcinogen present in tobacco smoke. DNA adducts induced by …
potent pulmonary carcinogen present in tobacco smoke. DNA adducts induced by …
In vivo and in vitro persistence of pyridyloxobutyl DNA adducts from 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone
LA Peterson, R Mathew, SE Murphy, N Trushin… - …, 1991 - academic.oup.com
The persistence of pyridyloxobutyl DNA adducts in lung and liver of F-344 rats treated with
the tobacco-specific nitrosamine 4-(methybiitrosamino)-1-(3-pyridyl)-1-butanone (NNK) was …
the tobacco-specific nitrosamine 4-(methybiitrosamino)-1-(3-pyridyl)-1-butanone (NNK) was …
Evidence for Phosphate Adducts in DNA from Mice Treated with 4-(N-Methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone (NNK)
J Haglund, AP Henderson, BT Golding… - Chemical research in …, 2002 - ACS Publications
The weakly alkylating capacity of phosphotriesters (PTE) has been used for the
determination of adducts to phosphate groups in DNA by specific transfer to the strongly …
determination of adducts to phosphate groups in DNA by specific transfer to the strongly …
Identification of O2-Substituted Pyrimidine Adducts Formed in Reactions of 4-(Acetoxymethylnitrosamino)- 1-(3-pyridyl)-1-butanone and 4-(Acetoxymethylnitros …
SS Hecht, PW Villalta, SJ Sturla, G Cheng… - Chemical research in …, 2004 - ACS Publications
Metabolic hydroxylation of the methyl group of the tobacco specific carcinogen 4-
(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and its metabolite 4 …
(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and its metabolite 4 …
Mass Spectrometric Quantitation of Pyridyloxobutyl DNA Phosphate Adducts in Rats Chronically Treated with N′-Nitrosonornicotine
The tobacco-specific carcinogens N′-nitrosonornicotine (NNN) and 4-(methylnitrosamino)-
1-(3-pyridyl)-1-butanone (NNK) require metabolic activation to exert their carcinogenicity …
1-(3-pyridyl)-1-butanone (NNK) require metabolic activation to exert their carcinogenicity …
Formation and repair of pyridyloxobutyl DNA adducts and their relationship to tumor yield in A/J mice
AM Urban, P Upadhyaya, Q Cao… - Chemical research in …, 2012 - ACS Publications
The nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is a known human
carcinogen. It generates methyl and pyridyloxobutyl DNA adducts. The role of the methyl …
carcinogen. It generates methyl and pyridyloxobutyl DNA adducts. The role of the methyl …
Formation and accumulation of pyridyloxobutyl DNA adducts in F344 rats chronically treated with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and enantiomers of …
Y Lao, N Yu, F Kassie, PW Villalta… - Chemical research in …, 2007 - ACS Publications
4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK, 1) and its metabolite, 4-
(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL, 2) are both potent pulmonary …
(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL, 2) are both potent pulmonary …