Optimized liquid chromatography nanoelectrospray–high-resolution tandem mass spectrometry method for the analysis of 4-hydroxy-1-(3-pyridyl)-1-butanone …
Metabolic activation of the carcinogenic tobacco-specific N-nitrosamines leads to the
formation of 4-hydroxy-1-(3-pyridyl)-1-butanone (HPB)-releasing DNA adducts. We recently …
formation of 4-hydroxy-1-(3-pyridyl)-1-butanone (HPB)-releasing DNA adducts. We recently …
Analysis of pyridyloxobutyl and pyridylhydroxybutyl DNA adducts in extrahepatic tissues of F344 rats treated chronically with 4-(methylnitrosamino)-1-(3-pyridyl)-1 …
S Zhang, M Wang, PW Villalta… - Chemical research in …, 2009 - ACS Publications
The tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and
its metabolite 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) are potent pulmonary …
its metabolite 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) are potent pulmonary …
Quantitation of pyridylhydroxybutyl-DNA adducts in liver and lung of F-344 rats treated with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and enantiomers of its …
P Upadhyaya, S Kalscheuer, JB Hochalter… - Chemical research in …, 2008 - ACS Publications
The tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is a
potent pulmonary carcinogen in rats and is believed to be one cause of lung cancer in …
potent pulmonary carcinogen in rats and is believed to be one cause of lung cancer in …
The influence of repair pathways on the cytotoxicity and mutagenicity induced by the pyridyloxobutylation pathway of tobacco-specific nitrosamines
L Li, J Perdigao, AE Pegg, Y Lao… - Chemical research in …, 2009 - ACS Publications
Tobacco-specific nitrosamines, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and N′-
nitrosonornicotine, are considered to be human carcinogens. Both compounds are …
nitrosonornicotine, are considered to be human carcinogens. Both compounds are …
Synthesis of DNA Oligonucleotides Containing Site-Specifically Incorporated O6-[4-Oxo-4-(3-pyridyl)butyl]guanine and Their Reaction with O6-Alkylguanine-DNA …
L Wang, TE Spratt, AE Pegg… - Chemical research in …, 1999 - ACS Publications
DNA pyridyloxobutylation occurs during the metabolic activation of the tobacco-specific
nitrosamines, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and N ' …
nitrosamines, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and N ' …
DNA single-strand breaks and toxicity induced by 4–(methyl-nitrosamino)–1–(3-pyridyl)-1-butanone or N-nitrosodimethylamine in hamster and rat liver
R Jorquera, A Castonguay, HM Schuller - Carcinogenesis, 1994 - academic.oup.com
Syrian golden hamsters and F344 rats display contrasting susceptibilities to
hepatocarcinogenesis induced by the tobacco-specific nitrosamine 4-(methylnitrosamino)-1 …
hepatocarcinogenesis induced by the tobacco-specific nitrosamine 4-(methylnitrosamino)-1 …
Identification of adducts formed by pyridyloxobutylation of deoxyguanosine and DNA by 4-(acetoxymethylnitrosamino)-1-(3-pyridyl)-1-butanone, a chemically activated …
M Wang, G Cheng, SJ Sturla, Y Shi… - Chemical research in …, 2003 - ACS Publications
The tobacco specific carcinogens 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)
and N '-nitrosonornicotine (NNN) are metabolically activated to 4-oxo-4-(3-pyridyl)-1 …
and N '-nitrosonornicotine (NNN) are metabolically activated to 4-oxo-4-(3-pyridyl)-1 …
[HTML][HTML] Metabolism and DNA Adduct Formation of Tobacco-Specific N-Nitrosamines
Y Li, SS Hecht - International journal of molecular sciences, 2022 - mdpi.com
The tobacco-specific N-nitrosamines 4-(N-nitrosomethylamino)-1-(3-pyridyl)-1-butanone
(NNK) and N′-nitrosonornicotine (NNN) always occur together and exclusively in tobacco …
(NNK) and N′-nitrosonornicotine (NNN) always occur together and exclusively in tobacco …
Extensive metabolic activation of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in smokers
I Stepanov, P Upadhyaya, SG Carmella, R Feuer… - … Biomarkers & Prevention, 2008 - AACR
(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is a potent lung carcinogen present in
both unburned tobacco and cigarette smoke. The sum of 4-(methylnitrosamino)-1-(3-pyridyl) …
both unburned tobacco and cigarette smoke. The sum of 4-(methylnitrosamino)-1-(3-pyridyl) …