4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) is a rodent carcinogen that is
metabolically derived from carbonyl reduction of 4-(methylnitrosamino)-1-(3-pyridyl)-1 …

Activation of the tobacco carcinogen 4 (methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)
produced methylating species and two aldehydes: formaldehyde and 4-oxo-4-(3-pyridyl) …

N-nitroso compounds represent a common type of environmental and endogenous DNA-
damaging agents. After metabolic activation, many N-nitroso compounds are converted into …

Two recent studies conducted in our laboratory have demonstrated formation and
accumulation of pyridyloxobutyl (POB) and pyridylhydroxybutyl (PHB) adducts in lung and …

The tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is a
lung carcinogen in rats and may be a cause of lung cancer in smokers. NNK is metabolized …

The tobacco-specific carcinogens 4-(methylnitrosamino)-l-(3-pyridyl)-l-butanone (NNK) and-
nitrosonornicotine (NNN) are metabolically activated to DNA binding intermediates, partially …

The tobacco-specific nitrosamines N′-nitrosonornicotine (NNN) and 4-(methylnitrosamino)-
1-(3-pyridyl)-1-butanone (NNK) are considered to be two of the most important carcinogens …

Exposure to the tobacco-specific N-nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-
butanone (NNK) is considered to be an important etiological risk factor for lung cancer in …

α-Acetoxy-N-nitrosopyrrolidine (α-acetoxyNPYR) is a stable precursor to α-hydroxyNPYR,
the initial product of metabolism and proposed proximate carcinogen of N-nitrosopyrrolidine …

We have synthesized 1-[IV3-(2'-deoxycytidyl)]-2-[N1-(2'-deoxyguanosinyl)] ethane and con-
firmed its structure by ultraviolet and high-resolution mass spectrometry. Treatment of calf …