alpha-Acetoxy-N-nitrosopyrrolidine (alpha-acetoxyNPYR) is a stable precursor to alpha-
hydroxyNPYR, the initial product of metabolism and proposed proximate carcinogen of …

Abstract The tobacco-specific nitrosamine, 4-(methylnitrosoamino)-1-(3-pyridyl)-1-butanone,
is activated to lung DNA methylating and pyridyloxobutylating intermediates. It is likely that …

4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is the most lung-specific of the
carcinogens present in tobacco smoke. Its bioactivation in cells leads to a small amount of …

An alkaline elution assay previously used to detect single-strand breaks in DNA of cultured
mammalian cells has been modified to allow the analysis of DNA damage in various organs …

Chronic inflammation is associated with a variety of human diseases, including cancer, with
one possible mechanistic link involving over-production of nitric oxide (NO) by activated …

Nitrosamines occur widespread in food, drinking water, cosmetics, as well as tobacco smoke
and can arise endogenously. More recently, nitrosamines have been detected as impurities …

Rabbit antibodies raised against O 6-methy1-2'-deoxyguanosine (O 6-MedGuo) were used
to develop a competitive BiotinAvidin enzyme-linked immunosorbent assay (BA-ELISA) for …

N '-Nitrosonornicotine (NNN) is believed to play an important role as a cause of cancer in
people who use tobacco products and is considered to be a human carcinogen. NNN …

N-Nitroso compounds (NOCs) are common DNA-alkylating agents, are abundantly present
in food and tobacco, and can also be generated endogenously. Metabolic activation of some …

Exposure of mammalian cells to alkylating agents causes transfer of alkyl groups to N-as
well as O-atoms of DNA bases. Especially the O-alkylated G and T bases have strong …