The emergence of multi-and extensively drug-resistant tuberculosis is a significant
impediment to the control of this disease because treatment becomes more complex and …

Conventional phenotypic drug susceptibility testing (DST) methods for Mycobacterium
tuberculosis are laborious and very time-consuming. Early detection of drug-resistant …

We developed a DNA sequencing-based method to detect mutations in the genome of drug-
resistant Mycobacterium tuberculosis. Drug resistance in M. tuberculosis is caused by …

Rationale: The development of molecular diagnostics that detect both the presence of
Mycobacterium tuberculosis in clinical samples and drug resistance–conferring mutations …

Molecular techniques can detect drug resistance in Mycobacterium tuberculosis, but
whether these methods are practical for clinical laboratory use and the management of …

The rapid detection of Mycobacterium tuberculosis isolates resistant to second-line drugs is
crucial for the institution of appropriate treatment regimens as early as possible. Although …

Background Drug resistance displays a problem for the therapy of Mycobacterium
tuberculosis infections. For molecular resistance testing, it is essential to have precise …

Drug-resistant tuberculosis has become a global problem and a major public health
concern. While mechanisms of resistance are fairly well characterized for most agents …

Novel tools are urgently needed for the rapid, reliable detection of multidrug-resistant (MDR)
and extensively drug-resistant (XDR) strains of Mycobacterium tuberculosis. To develop …

Past genotypic studies of Mycobacterium tuberculosis may have incorrectly estimated the
importance of specific drug resistance mutations due to a number of sampling biases …