The effects of temozolomide delivered by prolonged intracerebral microinfusion against the rat brainstem GBM allograft model
J Yoshimura, IM Siu, UW Thomale, GI Jallo - Child's Nervous System, 2012 - Springer
Objective Diffuse intrinsic brainstem gliomas are considered to be inoperable. We report our
initial experience of temozolomide (TMZ) administration into brainstem by intracerebral (ic) …
initial experience of temozolomide (TMZ) administration into brainstem by intracerebral (ic) …
Temozolomide delivered by intracerebral microinfusion is safe and efficacious against malignant gliomas in rats
AB Heimberger, GE Archer, RE McLendon… - Clinical cancer …, 2000 - AACR
Intracerebral microinfusion (ICM) is an innovative technique of delivering therapeutic agents
throughout large portions of the brain that circumvents the blood-brain barrier, minimizes …
throughout large portions of the brain that circumvents the blood-brain barrier, minimizes …
Local delivery of slow-releasing temozolomide microspheres inhibits intracranial xenograft glioma growth
J Dong, G Zhou, D Tang, Y Chen, B Cui, X Dai… - Journal of cancer …, 2012 - Springer
Background Currently, treatment of malignant gliomas with temozolomide in addition to
surgical resection and radiotherapy remains the foundation of glioma therapy. In an effort to …
surgical resection and radiotherapy remains the foundation of glioma therapy. In an effort to …
Intra-arterial temozolomide, osmotic blood-brain barrier disruption and radiotherapy in a rat F98-glioma model
AI Drapeau, MB Poirier, GS Madugundu… - Clinical Cancer …, 2017 - benthamdirect.com
Background: The blood-brain barrier (BBB) is a major obstacle in the treatment of brain
tumors. Intra-arterial (IA) administration with osmotic BBB disruption (BBBD) allows greater …
tumors. Intra-arterial (IA) administration with osmotic BBB disruption (BBBD) allows greater …
Combination of intracranial temozolomide with intracranial carmustine improves survival when compared with either treatment alone in a rodent glioma model
BACKGROUND: Local delivery of temozolomide (TMZ) through polymers is superior to oral
administration in a rodent glioma model. OBJECTIVE: We hypothesized that the observed …
administration in a rodent glioma model. OBJECTIVE: We hypothesized that the observed …
The temozolomide derivative 2T-P400 inhibits glioma growth via administration route of intravenous injection
R Li, D Tang, J Zhang, J Wu, L Wang, J Dong - Journal of neuro-oncology, 2014 - Springer
The aim of this study is to investigate the inhibitory effects of 2T-P400, a derivative of
temozolomide (TMZ), on glioma growth. SHG-44 and U373 human glioblastoma cell lines …
temozolomide (TMZ), on glioma growth. SHG-44 and U373 human glioblastoma cell lines …
Local delivery of temozolomide by biodegradable polymers is superior to oral administration in a rodent glioma model
S Brem, B Tyler, K Li, G Pradilla, F Legnani… - Cancer chemotherapy …, 2007 - Springer
Purpose Dose-limiting adverse effects of thrombocytopenia and leukopenia prevent
augmentation of current temozolomide (TMZ) dosing protocols; therefore, we hypothesized …
augmentation of current temozolomide (TMZ) dosing protocols; therefore, we hypothesized …
Intranasal administration of temozolomide for brain-targeting delivery: Therapeutic effect on glioma in rats
Y Li, Y Gao, G Liu, X Zhou, Y Wang… - Nan Fang yi ke da xue xue …, 2014 - europepmc.org
Objective To study the therapeutic effect of intranasal administration of temozolomide (TMZ)
for brain-targeting delivery in a rat model bearing orthotopic C6 glioma xenografts. Methods …
for brain-targeting delivery in a rat model bearing orthotopic C6 glioma xenografts. Methods …
Intra-arterial administration improves temozolomide delivery and efficacy in a model of intracerebral metastasis, but has unexpected brain toxicity
LL Muldoon, MA Pagel, JP Netto, EA Neuwelt - Journal of neuro-oncology, 2016 - Springer
We tested the hypothesis that intra-arterial (IA) infusion of temozolomide into the internal
carotid artery would safely improve drug delivery to brain and enhance chemotherapy …
carotid artery would safely improve drug delivery to brain and enhance chemotherapy …
Intratumoral temozolomide synergizes with immunotherapy in a T cell-dependent fashion
S Fritzell, E Sandén, S Eberstål, E Visse… - Cancer Immunology …, 2013 - Springer
Despite temozolomide (TMZ) treatment, the prognosis for patients with glioblastoma
multiforme is still dismal. As dose escalation of TMZ is limited by systemic toxicity …
multiforme is still dismal. As dose escalation of TMZ is limited by systemic toxicity …