Major hepatectomy or small‐for‐size liver transplantation may result in postoperative liver
failure. So far, no treatment is available to improve liver regeneration. Herein, we studied …

Liver failure after extended hepatectomy represents a major challenge in the surgery of
hepatic colorectal metastasis. A previous study has indicated that inhibition of …

Background Cilostazol is a type III phosphodiesterase inhibitor used to treat the symptoms of
intermittent claudication. Recent studies have shown that cilostazol decreases …

Background Focal hepatic venous outflow obstruction frequently occurs after extended liver
resection and leads to a portal hypertension, arterial hypoperfusion and parenchymal …

Abstract Background and Aims: Reactive oxygen species have been implicated in the
development of hepatic ischemia/reperfusion (I/R) injury. I/R injury remains an important …

The aim of the study was to determine if pretreatment with misoprostol (a prostaglandin
analogue) or nifedipine (a calcium antagonist), known protectants of the whole liver, would …

Background Evidence has suggested that immunosuppressive drugs impact ischemia–
reperfusion injury. Aims The purpose of the present study was to evaluate the effect of …

Background Sorafenib is a multikinase inhibitor with antiangiogenic and antiproliferative
properties, approved for the treatment of hepatocellular carcinoma. The effect of S orafenib …

AIM: To investigate the effect of E3-methyl-1-phenyl-2-pyrazolin-5-one (Edr) on hepatic
ischemia-reperfusion (I/R) injury and liver regeneration in a porcine hepatectomy model …

Cilostazol is a phosphodiesterase III inhibitor increases adenosine 3′, 5′-cyclic
monophosphate (cyclic AMP) level which inhibits hepatic stellate cell activation. Its …