Mesenchymal stromal cells (MSCs) of the bone marrow (BM) play key roles in regulating
hematopoietic function. Yet, knowledge on the compositional and functional dynamics of this …

CXCL12 is the major chemoattractant for hematopoietic stem cells (HSC) in the bone
marrow microenvironment (BMM), and plays a major role in HSC localization to their …

Mesenchymal stem cells (MSCs) in the bone marrow (BM) are thought to play pivotal roles in
tissue (re) generation and provide a supportive microenvironment for hematopoietic stem …

Hematopoietic cell transplantation has proven beneficial for various intractable diseases, but
it remains unclear how hematopoietic stem/progenitor cells (HSPCs) home to the bone …

Hematopoietic stem cells (HSCs) reside in specialized microenvironments (niches) in the
bone marrow. The stem cell niche is thought to provide signals that support key HSC …

In the bone marrow, the special microenvironment niches nurture a pool of hematopoietic
stem cells (HSCs). Many HSCs reside near the vasculature, but the molecular regulatory …

The regulation of hematopoietic stem cell (HSC) survival and self-renewal within the bone
marrow (BM) niche is not well understood. We therefore investigated global transcriptomic …

The CXC-type chemokine Cxcl12, also known as stromal cell–derived factor-1, plays a
critical role in hematopoiesis during fetal development. However, the functional requirement …

Bone marrow (BM) stromal cells provide the regulatory framework for hematopoiesis and
contribute to developmental stage-specific niches, such as those preserving hematopoietic …

Chronic myeloid leukemia (CML) results from hematopoietic stem cell (HSC) transformation
by the BCR-ABL tyrosine kinase. Tyrosine kinase inhibitors (TKI), although effective in …