The aim of the present study was to investigate the protective effect of S-ketamine (S-KET)
against carbon tetrachloride (CCl4)–induced liver damage and oxidative stress, as well as to …

Lipids, including cholesterol, are critical components of the cell membrane where they are
enriched in microdomains, lipid rafts, which organize and concentrate receptors and …

The 5-HT 6 R has been considered as an attractive therapeutic target in the brain due to its
exclusive expression in the brain. However, the mechanistic linkage between 5-HT 6 Rs and …

Hepatic encephalopathy (HE) is often associated with endogenous serotonin (5-HT)
disorders. However, the reason for elevated brain 5-HT levels due to liver failure remains …

Arachidonic acid (AA) signaling pathway is an important constituent of inflammatory
processes. In our previous study, it was found that dihydro-stilbene gigantol relieved hepatic …

The serotonin (5-HT) 6 receptor still raises particular interest given its unique spatio-
temporal pattern of expression among the serotonin receptor subtypes. It is the only …

Background: acute carbon tetrachloride (CCl4) intoxication in rats is strongly characterized
by the expression of numerous cytokines playing an important role in the pathophysiology of …

Liver diseases are one of the fatal disorders due to the vital role of the liver. Carbon
tetrachloride (CCl4) is the most perceived chemical substance utilized in developing models …

Abstract Aims (5R)-5-hydroxytriptolide (LLDT-8) is a triptolide analog with excellent
capability against cancers, cerebral ischemic injury and rheumatoid arthritis. Here, we …

In this study, we investigated whether serotonin could regulate the in vitro activity of
phagocytosis through 5‐hydroxytryptamine or serotonin (5‐HT1A) receptors. Mouse …