Several human neurodegenerative diseases such as Alzheimer's disease, Parkinson's
disease and Familial Amyloidotic Polyneuropathy, have long been associated with …

Protein function and flexibility is directly related to the native distribution of its structural
elements and any alteration in protein architecture leads to several abnormalities and …

Amyloids are a class of insoluble proteinaceous substances generally composed of linear
un-branched fibrils that are formed from misfolded proteins. Conformational diseases such …

Background Insulin is a hormone that regulates blood glucose homeostasis and is a central
protein in a medical condition termed insulin injection amyloidosis. It is intimately associated …

Protein glycation, also known as nonenzymatic glycosylation, is a spontaneous post-
translational modification that would change the structure and stability of proteins or …

Amyloidogenic diseases are characterised by the formation of amyloid aggregates inside or
outside the cell. Amyloid-associated human diseases include Alzheimer's disease …

Protein crucial function and flexibility directly depend on its whole structure which is
determined by the native distribution of structural elements. Any disturbances in a protein …

Neurodegenerative diseases are associated with misfolding and deposition of specific
proteins, either intra or extracellularly in the nervous system. Advanced glycation end …

The failure of protein to correctly fold into its functional and unique three dimensional form
leads to misfolded or partially folded protein. When these rogue proteins and polypeptides …

One of the grand challenges of biophysical chemistry is to understand the principles that
govern protein misfolding and aggregation, which is a highly complex process that is …