Cell signaling for T-cell growth, differentiation, and apoptosis is initiated in the cholesterol-
rich microdomains of the plasma membrane known as lipid rafts. Herein, we investigated …

Human aging is associated with an increase in immune cell cholesterol levels, independent
of circulating cholesterol levels. The effects of such an increase in membrane cholesterol on …

Liver X receptors (LXRs) are regulators of cholesterol metabolism that also modulate
immune responses. Inactivation of LXR α and β in mice leads to autoimmunity; however …

It is well established that cholesterol and glycosphingolipids are enriched in the plasma
membrane (PM) and form signaling platforms called lipid rafts, essential for T-cell activation …

Lipid rafts and caveolae play a pivotal role in organization of signaling by TLR4 and several
other immune receptors. Beyond the simple cataloguing of signaling events …

Lipid rafts are specialized plasma membrane microdomains, in which glycosphingolipids
and cholesterol are major structural components. In T lymphocytes, several signaling …

T lymphocytes contain two kinetic pools of cholesterol extractable with methyl-β-cyclodextrin
(m-β-CD): a fast pool (31.5%, t1/2= 17 s) and a slow pool (68.5%, t1/2= 15 min). Purification …

Lipid rafts reportedly have a role in coalescing key signaling molecules into the
immunological synapse during T cell activation, thereby modulating T cell receptor (TCR) …

In the last twenty years, the general view of the plasma membrane has changed from a
homogeneous arrangement of lipids to a mosaic of microdomains. It is currently thought that …

During the past decade, the lipid‐raft hypothesis has focused attention on the role of
membrane domains in controlling cellular functions. Among the best‐studied roles of lipid …