Therapy of acute myeloid leukemia: towards a patient-oriented, risk-adapted approach

F Mandelli, MC Petti, FL Coco - Haematologica, 1998 - haematologica.org
BACKGROUND AND OBJECTIVE: The successful use of differentiating treatment for
patients with acute promyelocytic leukemia (APL) suggests that other acute myeloid …

Genetic biomarkers in acute myeloid leukemia: will the promise of improving treatment outcomes be realized?

J Yang, CA Schiffer - Expert review of hematology, 2012 - Taylor & Francis
Recent progress in the molecular genetics of acute myeloid leukemia (AML) has shown this
disease to be more heterogeneous than previously realized. Recurrent cytogenetic and …

Genomic applications in the clinic: use in treatment paradigm of acute myeloid leukemia

RF Schlenk, H Döhner - Hematology 2013, the American …, 2013 - ashpublications.org
In recent years, research in genomics has resulted in the rapid uncovering of the molecular
pathogenesis of acute myeloid leukemia (AML). The identification of the genetic …

Molecular genetic pathways as therapeutic targets in acute myeloid leukemia

T Haferlach - ASH Education Program Book, 2008 - ashpublications.org
The heterogeneity of acute myeloid leukemia (AML) results from a complex network of
cytogenetic aberrations and molecular mutations. These genetic markers are the basis for …

The evolving molecular genetic landscape in acute myeloid leukaemia

MA Sanders, PJM Valk - Current opinion in hematology, 2013 - journals.lww.com
The list of acquired mutations with clinical value in AML is growing. Clinical implementation
of this multitude of markers will require integrated approaches and selection of markers to …

[HTML][HTML] Molecular characterization of acute myeloid leukemia

K Döhner, H Döhner - Haematologica, 2008 - haematologica.org
Acute myeloid leukemia (AML) is a genetically heterogeneous clonal disorder characterized
by the accumulation of acquired somatic genetic alterations in hematopoietic progenitor …

Acute myeloid leukemia and acute promyelocytic leukemia

B Löwenberg, JD Griffin… - ASH Education Program …, 2003 - ashpublications.org
The therapeutic approach to the patient with acute myeloid leukemia (AML) currently
evolves toward new frontiers. This is particularly apparent from the entree of high-throughput …

Current status and perspectives of therapy for acute myeloid leukemia

W Hiddemann, T Büchner - Seminars in hematology, 2001 - Elsevier
Intensification of induction and postremission chemotherapies has resulted in a steady
improvement in outcomes for adults with acute myeloid leukemia (AML) over the past two …

New strategies in acute myeloid leukemia: redefining prognostic markers to guide therapy

I Khan, JK Altman, JD Licht - Clinical Cancer Research, 2012 - AACR
Although standard therapy for AML has been relatively constant over the past 2 decades,
this may be changing with enhanced technologies allowing for the classification of acute …

Genetic mutations in acute myeloid leukemia that influence clinical decisions

SS Chung - Current opinion in hematology, 2014 - journals.lww.com
Genetic mutations in acute myeloid leukemia that influence c... : Current Opinion in Hematology
Genetic mutations in acute myeloid leukemia that influence clinical decisions : Current Opinion …