Distinct microbial and immune niches of the human colon
Gastrointestinal microbiota and immune cells interact closely and display regional
specificity; however, little is known about how these communities differ with location. Here …
specificity; however, little is known about how these communities differ with location. Here …
Comparative transcriptional and functional profiling defines conserved programs of intestinal DC differentiation in humans and mice
Dendritic cells (DCs) that orchestrate mucosal immunity have been studied in mice. Here we
characterized human gut DC populations and defined their relationship to previously studied …
characterized human gut DC populations and defined their relationship to previously studied …
[HTML][HTML] Intestinal epithelial cells promote colitis-protective regulatory T-cell differentiation through dendritic cell conditioning
Intestinal dendritic cells (DCs) have been shown to display specialized functions, including
the ability to promote gut tropism to lymphocytes, to polarize noninflammatory responses …
the ability to promote gut tropism to lymphocytes, to polarize noninflammatory responses …
Single-cell atlas of colonic CD8+ T cells in ulcerative colitis
D Corridoni, A Antanaviciute, T Gupta… - Nature medicine, 2020 - nature.com
Colonic antigen-experienced lymphocytes such as tissue-resident memory CD8+ T cells can
respond rapidly to repeated antigen exposure. However, their cellular phenotypes and the …
respond rapidly to repeated antigen exposure. However, their cellular phenotypes and the …
[HTML][HTML] CD4+ T cells persist for years in the human small intestine and display a TH1 cytokine profile
R Bartolomé-Casado, OJB Landsverk, SK Chauhan… - Mucosal …, 2021 - Elsevier
Studies in mice and humans have shown that CD8+ T cell immunosurveillance in non-
lymphoid tissues is dominated by resident populations. Whether CD4+ T cells use the same …
lymphoid tissues is dominated by resident populations. Whether CD4+ T cells use the same …
Focused specificity of intestinal TH17 cells towards commensal bacterial antigens
Abstract T-helper-17 (TH17) cells have critical roles in mucosal defence and in autoimmune
disease pathogenesis,,. They are most abundant in the small intestine lamina propria, where …
disease pathogenesis,,. They are most abundant in the small intestine lamina propria, where …
Innate lymphoid cells regulate CD4+ T-cell responses to intestinal commensal bacteria
Innate lymphoid cells (ILCs) are a recently characterized family of immune cells that have
critical roles in cytokine-mediated regulation of intestinal epithelial cell barrier integrity …
critical roles in cytokine-mediated regulation of intestinal epithelial cell barrier integrity …
[HTML][HTML] The transcription factor T-bet is induced by IL-15 and thymic agonist selection and controls CD8αα+ intraepithelial lymphocyte development
CSN Klose, K Blatz, Y d'Hargues, PP Hernandez… - Immunity, 2014 - cell.com
CD8αα+ intraepithelial lymphocytes (IELs) are instrumental in maintaining the epithelial
barrier in the intestine. Similar to natural killer cells and other innate lymphoid cells, CD8αα+ …
barrier in the intestine. Similar to natural killer cells and other innate lymphoid cells, CD8αα+ …
A RORγt+ cell instructs gut microbiota-specific Treg cell differentiation
The mutualistic relationship of gut-resident microbiota and the host immune system
promotes homeostasis that ensures maintenance of the microbial community and of a …
promotes homeostasis that ensures maintenance of the microbial community and of a …
CD8+ recent thymic emigrants home to and efficiently repopulate the small intestine epithelium
TL Staton, A Habtezion, MM Winslow, T Sato… - Nature …, 2006 - nature.com
Prevailing knowledge dictates that naive αβ T cells require activation in lymphoid tissues
before differentiating into effector or memory T cells capable of trafficking to nonlymphoid …
before differentiating into effector or memory T cells capable of trafficking to nonlymphoid …