Mice lacking the transcription factor T-bet in the innate immune system develop microbiota-
dependent colitis. Here, we show that interleukin-17A (IL-17A)-producing IL-7Rα+ innate …

Crohn's disease and ulcerative colitis are the two major forms of chronic relapsing
inflammatory disorders of the human intestines collectively referred to as inflammatory bowel …

Objective One of the current hypotheses to explain the proinflammatory immune response in
IBD is a dysregulated T cell reaction to yet unknown intestinal antigens. As such, it may be …

Group 3 innate lymphoid cells (ILC3s) are crucial for the maintenance of host–microbiota
homeostasis in gastrointestinal mucosal tissues. The mechanisms that maintain lineage …

The mammalian gut is colonized by numerous microorganisms collectively termed the
microbiota, which have a mutually beneficial relationship with their host,,. Normally, the gut …

Commensal bacteria shape the colonic regulatory T (Treg) cell population required for
intestinal tolerance. However, little is known about this process. Here, we use the transfer of …

Environmental enteric dysfunction (EED) is a gastrointestinal inflammatory disease caused
by malnutrition and chronic infection. EED is associated with stunting in children and …

Although CD103-expressing dendritic cells (DCs) are widely present in nonlymphoid
tissues, the transcription factors controlling their development and their relationship to other …

There is a growing appreciation for the importance of the gut microbiota as a therapeutic
target in various diseases. However, there are only a handful of known commensal strains …

Butyrophilin-like (Btnl) genes are emerging as major epithelial determinants of tissue-
associated γδ T cell compartments. Thus, the development of signature, murine TCRγδ+ …